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Onset of activity and time to response on individual CAPS-SX17 items in patients treated for post-traumatic stress disorder with venlafaxine ER: a pooled analysis

Record type: Article

This pooled analysis of data from two randomized, placebo-controlled trials of venlafaxine extended release (ER) assessed onset of activity and time to response on the 17 symptoms of post-traumatic stress disorder (PTSD) listed in DSM-IV and measured by the 17-item Clinician-Administered PTSD Scale (CAPS-SX17). The intent-to-treat (ITT) population comprised 687 patients (placebo, n=347; venlafaxine ER, n=340). Significant (p<0.05) separation between venlafaxine ER and placebo was observed on most CAPS-SX17 items, with earliest onset of activity and response (week 2) on items 5 (physiological reactivity on exposure to cues) and 14 (irritability or anger outbursts), and (week 4) items 1 (intrusive recollections) and 4 (psychological distress at exposure to cues). Onset of activity and response occurred later (generally, weeks 6-8) on items 9 (diminished interest/participation in activities), 10 (detachment or estrangement), 11 (restricted range of affect), 12 (sense of foreshortened future), all associated with numbing, 15 (difficulty concentrating), 16 (hypervigilance), 17 (exaggerated startle response), associated with hyperarousal, and 6 (avoidance of thoughts/feelings or conversations). Significant differences between venlafaxine ER and placebo were largely absent throughout the treatment period and at the primary week-12 end-point for items 2 (distressing dreams), 7 (avoidance of activities, places or people), 8 (inability to recall important aspect of trauma) and 13 (difficulty falling/staying asleep). These results indicate that symptoms of physiological reactivity and psychological distress in response to cues, and irritability/anger outbursts show early and robust improvement with venlafaxine ER treatment, while symptoms of numbing and hyperarousal take longer. The early and persistent effect of venlafaxine ER over placebo on anger/irritability is noteworthy in view of the clinical significance of these symptoms in PTSD.

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Citation

Stein, Dan J., Pedersen, Ron, Rothbaum, Barbara O., Baldwin, David S., Ahmed, Saeeduddin, Musgnung, Jeff and Davidson, Jonathan (2009) Onset of activity and time to response on individual CAPS-SX17 items in patients treated for post-traumatic stress disorder with venlafaxine ER: a pooled analysis International Journal of Neuropsychopharmacology, 12, (1), pp. 23-31. (doi:10.1017/S1461145708008961).

More information

Published date: February 2009
Keywords: affect, treatment, time, analysis, post-traumatic stress disorder, venlafaxine, patients

Identifiers

Local EPrints ID: 62614
URI: http://eprints.soton.ac.uk/id/eprint/62614
ISSN: 1461-1457
PURE UUID: 6d37fc35-6626-409d-8600-0010b24be1ab

Catalogue record

Date deposited: 24 Apr 2009
Last modified: 17 Jul 2017 14:20

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Contributors

Author: Dan J. Stein
Author: Ron Pedersen
Author: Barbara O. Rothbaum
Author: Saeeduddin Ahmed
Author: Jeff Musgnung
Author: Jonathan Davidson

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