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A randomized controlled trial of cognitive-behavior therapy for persistent symptoms in schizophrenia: a five-year follow-up

A randomized controlled trial of cognitive-behavior therapy for persistent symptoms in schizophrenia: a five-year follow-up
A randomized controlled trial of cognitive-behavior therapy for persistent symptoms in schizophrenia: a five-year follow-up
Meta-analyses of randomized controlled trials support the efficacy of cognitive behavioral therapy (CBT) in the treatment of symptoms of schizophrenia refractory to antipsychotic medication. This article addresses the issue of medium term durability. A five-year follow-up was undertaken of a sample of 90 subjects who participated in a randomized controlled trial of CBT and befriending (BF). Patients received routine care throughout the trial and the follow-up period. Intention to treat multivariate analysis was performed by an independent statistician following multiple imputation of missing data. Fifty-nine out of ninety patients were followed up at 5 years (CBT = 31, BF = 28). In comparison to BF and usual treatment, CBT showed evidence of a significantly greater and more durable effect on overall symptom severity (NNT = 10.36, CI ? 10.21, 10.51) and level of negative symptoms (NNT = 5.22, CI ? 5.06 ? 5.37). No difference was found between CBT and BF on either overall symptoms of schizophrenia or depression. The initial cost of an adjunctive course of CBT for individuals with medication refractory schizophrenia may be justified in light of symptomatic benefits that persist over the medium term.
therapy, schizophrenia
0920-9964
1-7
Turkington, Douglas
3e0aca69-c932-4fb6-9145-6e19c7310700
Sensky, Tom
e648bdf6-e429-4b79-bbf2-40b43a092b50
Scott, Jan
3630e0f5-fc6f-4bf3-ab8b-e2f243c89f99
Barnes, Thomas R.E.
3ae0ce78-0404-47dc-b54f-795ba8235e0e
Nur, Ula
79bb4da4-8104-4bb5-a6ed-41a98d180e01
Siddle, Ronald
0ea822f6-be8c-47f2-b092-f597b7cb0add
Hammond, Katherine
d535553c-80c7-4c6c-85ae-7477fb2f1d1b
Samarasekara, Neshika
f4a2edd5-3a1e-4d59-8bee-b4a8a030558f
Kingdon, David
14cdc422-10b4-4b2d-88ec-24fde5f4329b
Turkington, Douglas
3e0aca69-c932-4fb6-9145-6e19c7310700
Sensky, Tom
e648bdf6-e429-4b79-bbf2-40b43a092b50
Scott, Jan
3630e0f5-fc6f-4bf3-ab8b-e2f243c89f99
Barnes, Thomas R.E.
3ae0ce78-0404-47dc-b54f-795ba8235e0e
Nur, Ula
79bb4da4-8104-4bb5-a6ed-41a98d180e01
Siddle, Ronald
0ea822f6-be8c-47f2-b092-f597b7cb0add
Hammond, Katherine
d535553c-80c7-4c6c-85ae-7477fb2f1d1b
Samarasekara, Neshika
f4a2edd5-3a1e-4d59-8bee-b4a8a030558f
Kingdon, David
14cdc422-10b4-4b2d-88ec-24fde5f4329b

Turkington, Douglas, Sensky, Tom, Scott, Jan, Barnes, Thomas R.E., Nur, Ula, Siddle, Ronald, Hammond, Katherine, Samarasekara, Neshika and Kingdon, David (2008) A randomized controlled trial of cognitive-behavior therapy for persistent symptoms in schizophrenia: a five-year follow-up. Schizophrenia Research, 98 (1-3), 1-7. (doi:10.1016/j.schres.2007.09.026).

Record type: Article

Abstract

Meta-analyses of randomized controlled trials support the efficacy of cognitive behavioral therapy (CBT) in the treatment of symptoms of schizophrenia refractory to antipsychotic medication. This article addresses the issue of medium term durability. A five-year follow-up was undertaken of a sample of 90 subjects who participated in a randomized controlled trial of CBT and befriending (BF). Patients received routine care throughout the trial and the follow-up period. Intention to treat multivariate analysis was performed by an independent statistician following multiple imputation of missing data. Fifty-nine out of ninety patients were followed up at 5 years (CBT = 31, BF = 28). In comparison to BF and usual treatment, CBT showed evidence of a significantly greater and more durable effect on overall symptom severity (NNT = 10.36, CI ? 10.21, 10.51) and level of negative symptoms (NNT = 5.22, CI ? 5.06 ? 5.37). No difference was found between CBT and BF on either overall symptoms of schizophrenia or depression. The initial cost of an adjunctive course of CBT for individuals with medication refractory schizophrenia may be justified in light of symptomatic benefits that persist over the medium term.

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More information

e-pub ahead of print date: 23 October 2007
Published date: January 2008
Keywords: therapy, schizophrenia
Organisations: Faculty of Medicine, Clinical Neurosciences

Identifiers

Local EPrints ID: 62628
URI: http://eprints.soton.ac.uk/id/eprint/62628
ISSN: 0920-9964
PURE UUID: 39ad013f-209b-43f6-8b98-1d7d608041ae

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Date deposited: 06 Apr 2009
Last modified: 13 Mar 2019 20:27

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Contributors

Author: Douglas Turkington
Author: Tom Sensky
Author: Jan Scott
Author: Thomas R.E. Barnes
Author: Ula Nur
Author: Ronald Siddle
Author: Katherine Hammond
Author: Neshika Samarasekara
Author: David Kingdon

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