Analysis of the effect of memantine in reducing the worsening of clinical symptoms in patients with moderate to severe Alzheimer's disease
Analysis of the effect of memantine in reducing the worsening of clinical symptoms in patients with moderate to severe Alzheimer's disease
Background: Alzheimer's disease ( AD) is a progressive neurodegenerative disorder and delaying disease worsening is a relevant treatment outcome. Methods: Data from 6 randomized, double-blind, placebo-controlled, 6-month studies were pooled and a subgroup of patients ( 867 on placebo, 959 on memantine) with moderate to severe AD ( MiniMental State Examination < 20) was analyzed. 'Any clinical worsening' was defined as a decline on the Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-cog) or the Severe Impairment Battery ( SIB) and on the Clinician's Interview-Based Impression of Change Plus Caregiver In put (CIBIC-plus) and the Alzheimer's Disease Cooperative Study - Activities of Daily Living Inventory (ADCS-ADL), and 'marked clinical worsening' as 6 4 points decline on the ADAS-cog or 6 5 points on the SIB and decline on the CIBIC-plus and the ADCS-ADL. Results: More placebo-treated than memantine-treated patients showed any clinical worsening ( 28 vs. 18%; p < 0.001), and 21% placebo-treated patients compared to 11% memantine-treated patients had marked clinical worsening ( p < 0.001). Conclusion: In this population of moderate and severe AD patients, treatment with memantine was associated with reducing worsening of clinical symptoms in AD during the 6-month study period. Copyright (c) 2007 S. Karger AG, Basel
inventory, therapy, population, disorder, memory, clinical worsening, double-blind, alzheimer's disease, moderate, controlled-trial, placebo, treatment, cognitive, demented patients, severe impairment battery, impairment, disease, cibic-plus, symptoms, validity, adcs-adl, memantine, global, ad, scale, function
138-145
Wilkinson, D.
917ddca3-1dba-4e3c-8618-4db1f8b11800
Andersen, H.F.
23022aa3-3faf-4e24-848a-526652a6c893
2007
Wilkinson, D.
917ddca3-1dba-4e3c-8618-4db1f8b11800
Andersen, H.F.
23022aa3-3faf-4e24-848a-526652a6c893
Wilkinson, D. and Andersen, H.F.
(2007)
Analysis of the effect of memantine in reducing the worsening of clinical symptoms in patients with moderate to severe Alzheimer's disease.
Dementia and Geriatric Cognitive Disorders, 24 (2), .
(doi:10.1159/000105162).
Abstract
Background: Alzheimer's disease ( AD) is a progressive neurodegenerative disorder and delaying disease worsening is a relevant treatment outcome. Methods: Data from 6 randomized, double-blind, placebo-controlled, 6-month studies were pooled and a subgroup of patients ( 867 on placebo, 959 on memantine) with moderate to severe AD ( MiniMental State Examination < 20) was analyzed. 'Any clinical worsening' was defined as a decline on the Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-cog) or the Severe Impairment Battery ( SIB) and on the Clinician's Interview-Based Impression of Change Plus Caregiver In put (CIBIC-plus) and the Alzheimer's Disease Cooperative Study - Activities of Daily Living Inventory (ADCS-ADL), and 'marked clinical worsening' as 6 4 points decline on the ADAS-cog or 6 5 points on the SIB and decline on the CIBIC-plus and the ADCS-ADL. Results: More placebo-treated than memantine-treated patients showed any clinical worsening ( 28 vs. 18%; p < 0.001), and 21% placebo-treated patients compared to 11% memantine-treated patients had marked clinical worsening ( p < 0.001). Conclusion: In this population of moderate and severe AD patients, treatment with memantine was associated with reducing worsening of clinical symptoms in AD during the 6-month study period. Copyright (c) 2007 S. Karger AG, Basel
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Published date: 2007
Keywords:
inventory, therapy, population, disorder, memory, clinical worsening, double-blind, alzheimer's disease, moderate, controlled-trial, placebo, treatment, cognitive, demented patients, severe impairment battery, impairment, disease, cibic-plus, symptoms, validity, adcs-adl, memantine, global, ad, scale, function
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Local EPrints ID: 62650
URI: http://eprints.soton.ac.uk/id/eprint/62650
ISSN: 1420-8008
PURE UUID: f5213c0c-8055-440b-840a-192dff356d1c
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Date deposited: 09 Sep 2008
Last modified: 15 Mar 2024 11:31
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Author:
D. Wilkinson
Author:
H.F. Andersen
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