Cortex- and striatum-derived neural stem cells produce distinct progeny in the olfactory bulb and striatum
Cortex- and striatum-derived neural stem cells produce distinct progeny in the olfactory bulb and striatum
Neural stem cells can be isolated from the mouse embryonic cortex but do not persist in the adult cortex. In contrast, neural stem cells from the striatal embryonic germinal zone persist in the adult subependyma. Emx1-lineage analysis revealed that cortex-derived neural stem cells survive and migrate ventrally into the subependyma where they intermix with the host striatal neural stem cells [S. Willaime-Morawek et al. (2006) J. Cell Biol. 175, 159-168]. Cortex-derived cells proliferate faster in the subependyma and reach the olfactory bulb earlier than striatum-derived cells. In the olfactory bulb, cortex-derived cells produce more cells and more dopaminergic neurons in the glomerular layer than striatum-derived cells. Cortex-derived cells also give rise to more astrocytes and less neurons in the striatum than striatum-derived cells. Thus, history matters; cortex-derived neural stem cells in the subependyma give rise to progeny in the olfactory bulb and striatum but in different proportions than striatum-derived neural stem cells.
cell migration, mus musculus, neuron, pax, neural stem cells, subventricular zone, cells, adult-mouse brain, proliferation, stem cells, astrocytes, fate, cerebral-cortex, neurogenesis, genes, interneurons, neurons, stem cell
2354-2362
Willaime-Morawek, S.
24a2981f-aa9e-4bf6-ad12-2ccf6b49f1c0
Van der Kooy, D.
b9a759b8-56ec-4059-9421-02337257fa16
May 2008
Willaime-Morawek, S.
24a2981f-aa9e-4bf6-ad12-2ccf6b49f1c0
Van der Kooy, D.
b9a759b8-56ec-4059-9421-02337257fa16
Willaime-Morawek, S. and Van der Kooy, D.
(2008)
Cortex- and striatum-derived neural stem cells produce distinct progeny in the olfactory bulb and striatum.
European Journal of Neuroscience, 27 (9), .
(doi:10.1111/j.1460-9568.2008.06206.x).
(PMID:18445225)
Abstract
Neural stem cells can be isolated from the mouse embryonic cortex but do not persist in the adult cortex. In contrast, neural stem cells from the striatal embryonic germinal zone persist in the adult subependyma. Emx1-lineage analysis revealed that cortex-derived neural stem cells survive and migrate ventrally into the subependyma where they intermix with the host striatal neural stem cells [S. Willaime-Morawek et al. (2006) J. Cell Biol. 175, 159-168]. Cortex-derived cells proliferate faster in the subependyma and reach the olfactory bulb earlier than striatum-derived cells. In the olfactory bulb, cortex-derived cells produce more cells and more dopaminergic neurons in the glomerular layer than striatum-derived cells. Cortex-derived cells also give rise to more astrocytes and less neurons in the striatum than striatum-derived cells. Thus, history matters; cortex-derived neural stem cells in the subependyma give rise to progeny in the olfactory bulb and striatum but in different proportions than striatum-derived neural stem cells.
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Willaime-Morawek_EJN_2008.pdf
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e-pub ahead of print date: 25 April 2008
Published date: May 2008
Keywords:
cell migration, mus musculus, neuron, pax, neural stem cells, subventricular zone, cells, adult-mouse brain, proliferation, stem cells, astrocytes, fate, cerebral-cortex, neurogenesis, genes, interneurons, neurons, stem cell
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Medicine
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Local EPrints ID: 62653
URI: http://eprints.soton.ac.uk/id/eprint/62653
ISSN: 0953-816X
PURE UUID: 6558357d-4ccd-4008-8143-bcd728196eb5
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Date deposited: 12 Sep 2008
Last modified: 16 Mar 2024 03:57
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Author:
D. Van der Kooy
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