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Meta-analysis of clinical outcome after first and second liver resection for colorectal metastases

Meta-analysis of clinical outcome after first and second liver resection for colorectal metastases
Meta-analysis of clinical outcome after first and second liver resection for colorectal metastases
Background
The perioperative risk and long-term survival benefit of repeat hepatectomy for patients with liver metastases from colorectal cancer, compared with that of a first liver resection, has been reported with varying results in the literature.
Methods
The literature was searched using Medline, Embase, Ovid, and Cochrane databases for all studies published from 1992 to 2006. Two authors independently extracted data using the following outcomes: postoperative complications and mortality; disease recurrence; and long-term survival. Trials were assessed using the modified Newcastle-Ottawa Score. Random-effect meta-analytical techniques were used for analysis.
Results
Twenty-one studies met the inclusion criteria, comprising 3,741 patients. The use of adjuvant chemotherapy was similar in both groups (odds ratio [OR] = 0.97; 95% confidence interval [CI] = 0.54, 1.74; P = .92), as was the number of hepatic nodules present at the time of first or second resection (weighted mean difference [WMD] = 0.18; 95% CI = ?0.22, 0.57; P = .380). Wedge resection was carried out less often at first hepatectomy (39% vs 46%; OR = 0.66; 95% CI = 0.44, 1.00; P = .05). There was significantly less blood loss in patients undergoing first versus second hepatectomy (WMD = 238 ml; 95% CI = 90, 385; P = .002). There was no difference in perioperative morbidity (OR = 1.01; 95% CI = 0.65, 1.55; P = .98), mortality (OR = 1.01; 95% CI = 0.18, 5.72; P = .99) or long-term survival (HR = 0.90; 95% CI = .66, 1.24; P = .530) between groups.
Conclusions
Repeat hepatectomy for patients with colorectal cancer metastases is safe and provides survival benefit equal to that of a first liver resection.
outcomes, survival, mortality, recurrent metastases, central venous-pressure, repeat hepatic resection, natural-history, elderly-patients, colorectal-cancer, liver resection, liver, carcinoma, colorectal metastases, disease, radiofrequency ablation, cancer, hepatectomy
0039-6060
9-18
Antoniou, Anthony
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Lovegrove, Richard E.
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Tilney, Henry S.
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Heriot, Alexander G.
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John, Timothy G.
78e0c300-b275-4fbd-ad7a-9fe78f7f6734
Rees, Myrddin
f35b89e2-e207-439f-b685-7b6dcbaea214
Tekkis, Paris P.
c042bcd5-7b60-4cc0-8881-5015eb430560
Welch, Fenella K.S.
7b975ce5-5e46-4383-8818-0d3ca8a6a5c4
Antoniou, Anthony
538efe60-8406-4414-ba43-9946d50f74c8
Lovegrove, Richard E.
3dfcc2c1-3f55-4e86-b997-4b2536814edf
Tilney, Henry S.
94e572b8-e8b0-4323-8100-f9aecd722cf2
Heriot, Alexander G.
e8d30c7f-3780-4884-9b68-e89697fa0c6c
John, Timothy G.
78e0c300-b275-4fbd-ad7a-9fe78f7f6734
Rees, Myrddin
f35b89e2-e207-439f-b685-7b6dcbaea214
Tekkis, Paris P.
c042bcd5-7b60-4cc0-8881-5015eb430560
Welch, Fenella K.S.
7b975ce5-5e46-4383-8818-0d3ca8a6a5c4

Antoniou, Anthony, Lovegrove, Richard E., Tilney, Henry S., Heriot, Alexander G., John, Timothy G., Rees, Myrddin, Tekkis, Paris P. and Welch, Fenella K.S. (2007) Meta-analysis of clinical outcome after first and second liver resection for colorectal metastases. Surgery, 141 (1), 9-18. (doi:10.1016/j.surg.2006.07.045).

Record type: Article

Abstract

Background
The perioperative risk and long-term survival benefit of repeat hepatectomy for patients with liver metastases from colorectal cancer, compared with that of a first liver resection, has been reported with varying results in the literature.
Methods
The literature was searched using Medline, Embase, Ovid, and Cochrane databases for all studies published from 1992 to 2006. Two authors independently extracted data using the following outcomes: postoperative complications and mortality; disease recurrence; and long-term survival. Trials were assessed using the modified Newcastle-Ottawa Score. Random-effect meta-analytical techniques were used for analysis.
Results
Twenty-one studies met the inclusion criteria, comprising 3,741 patients. The use of adjuvant chemotherapy was similar in both groups (odds ratio [OR] = 0.97; 95% confidence interval [CI] = 0.54, 1.74; P = .92), as was the number of hepatic nodules present at the time of first or second resection (weighted mean difference [WMD] = 0.18; 95% CI = ?0.22, 0.57; P = .380). Wedge resection was carried out less often at first hepatectomy (39% vs 46%; OR = 0.66; 95% CI = 0.44, 1.00; P = .05). There was significantly less blood loss in patients undergoing first versus second hepatectomy (WMD = 238 ml; 95% CI = 90, 385; P = .002). There was no difference in perioperative morbidity (OR = 1.01; 95% CI = 0.65, 1.55; P = .98), mortality (OR = 1.01; 95% CI = 0.18, 5.72; P = .99) or long-term survival (HR = 0.90; 95% CI = .66, 1.24; P = .530) between groups.
Conclusions
Repeat hepatectomy for patients with colorectal cancer metastases is safe and provides survival benefit equal to that of a first liver resection.

Full text not available from this repository.

More information

Published date: January 2007
Keywords: outcomes, survival, mortality, recurrent metastases, central venous-pressure, repeat hepatic resection, natural-history, elderly-patients, colorectal-cancer, liver resection, liver, carcinoma, colorectal metastases, disease, radiofrequency ablation, cancer, hepatectomy

Identifiers

Local EPrints ID: 62672
URI: https://eprints.soton.ac.uk/id/eprint/62672
ISSN: 0039-6060
PURE UUID: d98fcdd7-6e99-40b7-8a9b-a31e6a4cd440

Catalogue record

Date deposited: 11 Sep 2008
Last modified: 13 Mar 2019 20:27

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