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Multispike interactions in a stochastic model of spike-timing-dependent plasticity

Multispike interactions in a stochastic model of spike-timing-dependent plasticity
Multispike interactions in a stochastic model of spike-timing-dependent plasticity
Recently we presented a stochastic, ensemble-based model of spike-timing-dependent plasticity. In this model, single synapses do not exhibit plasticity depending on the exact timing of pre- and postsynaptic spikes, but spike-timing-dependent plasticity emerges only at the temporal or synaptic ensemble level. We showed that such a model reproduces a variety of experimental results in a natural way, without the introduction of various, ad hoc nonlinearities characteristic of some alternative models. Our previous study was restricted to an examination, analytically, of two-spike interactions, while higher-order, multispike interactions were only briefly examined numerically. Here we derive exact, analytical results for the general n-spike interaction functions in our model. Our results form the basis for a detailed examination, performed elsewhere, of the significant differences between these functions and the implications these differences have for the presence, or otherwise, of stable, competitive dynamics in our model.
bidirectional synaptic plasticity, model, models, time, synapses
1362-1399
Appleby, Peter A.
ac76e97a-553b-441f-ad81-0a9c511727d6
Elliott, Terry
b4262f0d-c295-4ea4-b5d8-3931470952f9
Appleby, Peter A.
ac76e97a-553b-441f-ad81-0a9c511727d6
Elliott, Terry
b4262f0d-c295-4ea4-b5d8-3931470952f9

Appleby, Peter A. and Elliott, Terry (2007) Multispike interactions in a stochastic model of spike-timing-dependent plasticity. Neural Computation, 19 (5), 1362-1399. (doi:10.1162/neco.2007.19.5.1362).

Record type: Article

Abstract

Recently we presented a stochastic, ensemble-based model of spike-timing-dependent plasticity. In this model, single synapses do not exhibit plasticity depending on the exact timing of pre- and postsynaptic spikes, but spike-timing-dependent plasticity emerges only at the temporal or synaptic ensemble level. We showed that such a model reproduces a variety of experimental results in a natural way, without the introduction of various, ad hoc nonlinearities characteristic of some alternative models. Our previous study was restricted to an examination, analytically, of two-spike interactions, while higher-order, multispike interactions were only briefly examined numerically. Here we derive exact, analytical results for the general n-spike interaction functions in our model. Our results form the basis for a detailed examination, performed elsewhere, of the significant differences between these functions and the implications these differences have for the presence, or otherwise, of stable, competitive dynamics in our model.

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More information

Published date: May 2007
Keywords: bidirectional synaptic plasticity, model, models, time, synapses

Identifiers

Local EPrints ID: 62676
URI: https://eprints.soton.ac.uk/id/eprint/62676
PURE UUID: e54a5b75-ad32-4415-822f-edcc2efb684f

Catalogue record

Date deposited: 11 Sep 2008
Last modified: 13 Mar 2019 20:27

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Contributors

Author: Peter A. Appleby
Author: Terry Elliott

University divisions

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