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C-terminal binding proteins: Emerging roles in cell survival and tumorigenesis

C-terminal binding proteins: Emerging roles in cell survival and tumorigenesis
C-terminal binding proteins: Emerging roles in cell survival and tumorigenesis
Within a cell, the levels and activity of multiple pro- and anti-apoptotic molecules act in concert to regulate commitment to apoptosis. Whilst the balance between survival and death can be tipped by the effects of single molecules, cellular apoptosis control pathways very often incorporate key transcription factors that co-ordinately regulate the expression of multiple apoptosis control genes. C-terminal binding proteins (CtBPs), which were originally identified through their binding to the Adenovirus E1A oncoprotein, have been described as such transcriptional regulators of the apoptosis program. Specifically, CtBPs function as transcriptional co-repressors, and have been demonstrated to promote cell survival by suppressing the expression of several pro-apoptotic genes. In this review we summarize the evidence supporting a key role for CtBP proteins in cell survival. We also describe the known mechanisms of transcriptional control by CtBPs, and review the multiplicity of intracellular signaling and transcriptional control pathways with which they are known to be involved. Finally we consider these findings in the context of additional known roles of CtBP molecules, and the potential implications that this combined knowledge may have for our comprehension of diseases of cell survival, notably cancer
transcriptional repressor snail, binding-protein, molecular-cloning, oncogenic transformation, corepressor ctbp, transcriptional repression, negative modulation, interacting protein, apoptosis, tumor-suppressor, transcription, expression, disease, e-cadherin, golgi, ctbp, transcriptional corepressor, protein, survival, cancer, dna-damage, adenovirus e1a protein, gene
1360-8185
879-888
Bergman, L.M.
965d18c2-2294-4f7a-a268-177e31df5492
Blaydes, J.P.
e957f999-fd91-4f77-ad62-5b4ef069b15b
Bergman, L.M.
965d18c2-2294-4f7a-a268-177e31df5492
Blaydes, J.P.
e957f999-fd91-4f77-ad62-5b4ef069b15b

Bergman, L.M. and Blaydes, J.P. (2006) C-terminal binding proteins: Emerging roles in cell survival and tumorigenesis. Apoptosis, 11 (6), 879-888. (doi:10.1007/s10495-006-6651-4).

Record type: Article

Abstract

Within a cell, the levels and activity of multiple pro- and anti-apoptotic molecules act in concert to regulate commitment to apoptosis. Whilst the balance between survival and death can be tipped by the effects of single molecules, cellular apoptosis control pathways very often incorporate key transcription factors that co-ordinately regulate the expression of multiple apoptosis control genes. C-terminal binding proteins (CtBPs), which were originally identified through their binding to the Adenovirus E1A oncoprotein, have been described as such transcriptional regulators of the apoptosis program. Specifically, CtBPs function as transcriptional co-repressors, and have been demonstrated to promote cell survival by suppressing the expression of several pro-apoptotic genes. In this review we summarize the evidence supporting a key role for CtBP proteins in cell survival. We also describe the known mechanisms of transcriptional control by CtBPs, and review the multiplicity of intracellular signaling and transcriptional control pathways with which they are known to be involved. Finally we consider these findings in the context of additional known roles of CtBP molecules, and the potential implications that this combined knowledge may have for our comprehension of diseases of cell survival, notably cancer

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Published date: 2006
Keywords: transcriptional repressor snail, binding-protein, molecular-cloning, oncogenic transformation, corepressor ctbp, transcriptional repression, negative modulation, interacting protein, apoptosis, tumor-suppressor, transcription, expression, disease, e-cadherin, golgi, ctbp, transcriptional corepressor, protein, survival, cancer, dna-damage, adenovirus e1a protein, gene

Identifiers

Local EPrints ID: 62689
URI: http://eprints.soton.ac.uk/id/eprint/62689
ISSN: 1360-8185
PURE UUID: 563f6dfc-02de-4262-8335-742d06e6863b
ORCID for J.P. Blaydes: ORCID iD orcid.org/0000-0001-8525-0209

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Date deposited: 08 Sep 2008
Last modified: 03 Dec 2019 01:53

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Contributors

Author: L.M. Bergman
Author: J.P. Blaydes ORCID iD

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