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Prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with surgically resectable adenocarcinoma of the oesophagus

Prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with surgically resectable adenocarcinoma of the oesophagus
Prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with surgically resectable adenocarcinoma of the oesophagus
Background: COX-2 expression in tumour cells has been associated with poor prognosis in gastrointestinal and non-gastrointestinal cancers. The aim of our study was to test the hypothesis that higher levels of COX-2 expression are prognostically related to poor clinico-pathologic features in adenocarcinoma of the oesophagus. Methods: We reviewed the records of 100 consecutive patients undergoing resection for adenocarcinoma of the oesophagus to collect data on T-stage, N-stage, tumour recurrence and survival. T & N-stage was further confirmed by histological examination. COX-2 protein expression was assessed by immunohistochemistry in all patients and COX-2 m-RNA expression was measured by quantitative RT-PCR in a small group of patients. Results: Higher levels of COX-2 expression were associated with higher T stage ( p = 0.008), higher N stage ( p = 0.049), increased risk of tumour recurrence ( p = 0.01) and poor survival ( p = 200 was associated with a median survival of 10 months compared to 26 months with a score of < 200 ( p = < 0.001). Conclusion: Higher levels of COX-2 expression are associated with poor clinico-pathologic features and poor survival in patients with oesophageal adenocarcinoma.
protein, cancer cells, prognostic-significance, risk, colon carcinogenesis, inhibitor, patient, cancer, apoptosis, synthase, poor-prognosis, angiogenesis, expression, prognosis, carcinoma, survival, immunohistochemistry, cells, polyposis, celecoxib, adenocarcinoma, time, features, up-regulation, cell
1471-2407
9pp.
Bhandari, Pradeep
5d6f89f0-a69d-48d7-b182-95e7f400e1c9
Bateman, Adrian C.
28ae82e3-b93a-429a-81f5-04e8f1ff4cc7
Mehta, Raj L.
00c133aa-709b-4483-b2ee-50b835a1b8a4
Stacey, Bernard S.F.
8136bc51-2ca8-457f-b923-4b6681cf656d
Johnson, Penny
3f6068ce-171e-4c2c-aca9-dc9b6a37413f
Cree, Ian A.
c1c5f52c-365f-4768-8b03-b62e249cefaa
Di Nicolantonio, Federica
0e4986ff-e4a0-4a9d-8af5-21c99c6bd836
Patel, Praful
c92dd012-6d09-43b2-9fac-aaadcb42ea27
Bhandari, Pradeep
5d6f89f0-a69d-48d7-b182-95e7f400e1c9
Bateman, Adrian C.
28ae82e3-b93a-429a-81f5-04e8f1ff4cc7
Mehta, Raj L.
00c133aa-709b-4483-b2ee-50b835a1b8a4
Stacey, Bernard S.F.
8136bc51-2ca8-457f-b923-4b6681cf656d
Johnson, Penny
3f6068ce-171e-4c2c-aca9-dc9b6a37413f
Cree, Ian A.
c1c5f52c-365f-4768-8b03-b62e249cefaa
Di Nicolantonio, Federica
0e4986ff-e4a0-4a9d-8af5-21c99c6bd836
Patel, Praful
c92dd012-6d09-43b2-9fac-aaadcb42ea27

Bhandari, Pradeep, Bateman, Adrian C., Mehta, Raj L., Stacey, Bernard S.F., Johnson, Penny, Cree, Ian A., Di Nicolantonio, Federica and Patel, Praful (2006) Prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with surgically resectable adenocarcinoma of the oesophagus. BMC cancer, 6 (Article no. 134), 9pp.. (doi:10.1186/1471-2407-6-134).

Record type: Article

Abstract

Background: COX-2 expression in tumour cells has been associated with poor prognosis in gastrointestinal and non-gastrointestinal cancers. The aim of our study was to test the hypothesis that higher levels of COX-2 expression are prognostically related to poor clinico-pathologic features in adenocarcinoma of the oesophagus. Methods: We reviewed the records of 100 consecutive patients undergoing resection for adenocarcinoma of the oesophagus to collect data on T-stage, N-stage, tumour recurrence and survival. T & N-stage was further confirmed by histological examination. COX-2 protein expression was assessed by immunohistochemistry in all patients and COX-2 m-RNA expression was measured by quantitative RT-PCR in a small group of patients. Results: Higher levels of COX-2 expression were associated with higher T stage ( p = 0.008), higher N stage ( p = 0.049), increased risk of tumour recurrence ( p = 0.01) and poor survival ( p = 200 was associated with a median survival of 10 months compared to 26 months with a score of < 200 ( p = < 0.001). Conclusion: Higher levels of COX-2 expression are associated with poor clinico-pathologic features and poor survival in patients with oesophageal adenocarcinoma.

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Published date: May 2006
Keywords: protein, cancer cells, prognostic-significance, risk, colon carcinogenesis, inhibitor, patient, cancer, apoptosis, synthase, poor-prognosis, angiogenesis, expression, prognosis, carcinoma, survival, immunohistochemistry, cells, polyposis, celecoxib, adenocarcinoma, time, features, up-regulation, cell

Identifiers

Local EPrints ID: 62691
URI: http://eprints.soton.ac.uk/id/eprint/62691
ISSN: 1471-2407
PURE UUID: afb7d974-fda7-49be-8da0-e242fbe24b95
ORCID for Penny Johnson: ORCID iD orcid.org/0000-0003-2306-4974

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Date deposited: 15 Apr 2009
Last modified: 05 Nov 2019 01:58

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