Bhandari, Pradeep, Bateman, Adrian C., Mehta, Raj L., Stacey, Bernard S.F., Johnson, Penny, Cree, Ian A., Di Nicolantonio, Federica and Patel, Praful (2006) Prognostic significance of cyclooxygenase-2 (COX-2) expression in patients with surgically resectable adenocarcinoma of the oesophagus. BMC cancer, 6 (Article no. 134), 9pp.. (doi:10.1186/1471-2407-6-134).
Abstract
Background: COX-2 expression in tumour cells has been associated with poor prognosis in gastrointestinal and non-gastrointestinal cancers. The aim of our study was to test the hypothesis that higher levels of COX-2 expression are prognostically related to poor clinico-pathologic features in adenocarcinoma of the oesophagus. Methods: We reviewed the records of 100 consecutive patients undergoing resection for adenocarcinoma of the oesophagus to collect data on T-stage, N-stage, tumour recurrence and survival. T & N-stage was further confirmed by histological examination. COX-2 protein expression was assessed by immunohistochemistry in all patients and COX-2 m-RNA expression was measured by quantitative RT-PCR in a small group of patients. Results: Higher levels of COX-2 expression were associated with higher T stage ( p = 0.008), higher N stage ( p = 0.049), increased risk of tumour recurrence ( p = 0.01) and poor survival ( p = 200 was associated with a median survival of 10 months compared to 26 months with a score of < 200 ( p = < 0.001). Conclusion: Higher levels of COX-2 expression are associated with poor clinico-pathologic features and poor survival in patients with oesophageal adenocarcinoma.
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