The University of Southampton
University of Southampton Institutional Repository

Intrinsic versus extrinsic influences in the development of neuronal maps

Record type: Article

Accumulating evidence suggests that the plasticity of extrinsic thalamocortical inputs in cortical layer IV may be guided or instructed by earlier plasticity events in the intrinsic, horizontal connections within the extragranular cortical layers. We analyse a rate-based model of the plasticity of a set of extrinsic afferents in the presence of a pre-existing (and fixed) plexus of intrinsic, overall excitatory horizontal connections between a set of target neurons. We determine conditions under which afferent synaptic pattern formation respects this pre-existing lateral structure. We find three broad regimes under which extrinsic afferent plasticity may violate this structure: the initial pattern of extrinsic afferent innervation of the target cells is far from balanced; the gain of the extrinsic afferents greatly exceeds the overall scale of the strength of lateral excitation; the target cell horizontal coupling matrix is sparse. If none of these conditions is satisfied, then extrinsic afferent plasticity respects the pre-existing lateral connectivity, so that afferent synaptic pattern formation conforms to the pattern of lateral excitation.

Full text not available from this repository.

Citation

Elliott, Terry (2007) Intrinsic versus extrinsic influences in the development of neuronal maps Biological Cybernetics, 96, (1), pp. 129-143. (doi:10.1007/s00422-006-0103-7).

More information

Published date: 7 September 2007
Keywords: model, striate cortex, ocular dominance columns, cat, time, critical period, cell, horizontal connections, primary visual-cortex, development, cells, local circuits, cortical maps, plasticity

Identifiers

Local EPrints ID: 62732
URI: http://eprints.soton.ac.uk/id/eprint/62732
ISSN: 0340-1200
PURE UUID: 27889a55-fa4a-48b2-a7be-9cff6e1f5ee1

Catalogue record

Date deposited: 04 Sep 2008
Last modified: 17 Jul 2017 14:20

Export record

Altmetrics

Contributors

Author: Terry Elliott

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×