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Predictive genetic testing for BRCA1/2 in a UK clinical cohort: three-year follow-up

Predictive genetic testing for BRCA1/2 in a UK clinical cohort: three-year follow-up
Predictive genetic testing for BRCA1/2 in a UK clinical cohort: three-year follow-up
This prospective multicentre study assesses long-term impact of genetic testing for breast/ovarian cancer predisposition in a clinical cohort. Areas evaluated include risk management, distress and insurance problems 3 years post-testing. Participants are adults unaffected with cancer from families with a known BRCA1/2 mutation. One hundred and ninety-three out of 285 (70% response) participants at nine UK clinical genetics centres completed assessments at 3 years: 80% female; 37% carriers of a BRCA1/2 mutation. In the 3 years, post-genetic testing carriers reported more risk management activities than non-carriers. Fifty-five per cent of female carriers opted for risk reducing surgery; 43% oophorectomy; and 34% mastectomy. Eighty-nine per cent had mammograms compared with 47% non-carriers. Thirty-six per cent non-carriers >= 50 years did not have a mammogram post-test. Twenty-two per cent male carriers had colorectal and 44% prostate screening compared with 5 and 19% non-carriers respectively. Seven per cent carriers and 1% non-carriers developed cancer. Distress levels did not differ in carriers and non- carriers at 3-year follow-up. Forty per cent of female carriers reported difficulties with life and/or health insurance. Given the return to pre-test levels of concern among female non- carriers at 3 years and a substantial minority not engaging in recommended screening, there appears to be a need to help some women understand the meaning of their genetic status
genetic testing, risk management, psychological, BRCA1/2
0007-0920
718-724
Foster, C.
00786ac1-bd47-4aeb-a0e2-40e058695b73
Watson, M.
168c5230-279a-4c51-9065-eefcd18191fa
Eeles, R.
c7ae2359-6f49-4f42-88f8-a241570f9d4f
Eccles, D.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Ashley, S.
e742da83-3a74-4c9c-9d79-3993a69f3660
Davidson, R.
9f684474-a989-4d8c-988c-a42e3d19db25
Mackay, J.
8a2363bb-013c-415a-ba9b-77aee80d1002
Morrison, P.J.
cdcdba90-397b-4345-b409-7e2d1e1282d4
Hopwood, P.
aed6184b-149a-4459-b68e-87a9e22241f0
Evans, D.G.R.
2fd1ea41-abdf-4d13-a2a3-afa9ba2f4c12
Psychosocial Study Collaborators
Foster, C.
00786ac1-bd47-4aeb-a0e2-40e058695b73
Watson, M.
168c5230-279a-4c51-9065-eefcd18191fa
Eeles, R.
c7ae2359-6f49-4f42-88f8-a241570f9d4f
Eccles, D.
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Ashley, S.
e742da83-3a74-4c9c-9d79-3993a69f3660
Davidson, R.
9f684474-a989-4d8c-988c-a42e3d19db25
Mackay, J.
8a2363bb-013c-415a-ba9b-77aee80d1002
Morrison, P.J.
cdcdba90-397b-4345-b409-7e2d1e1282d4
Hopwood, P.
aed6184b-149a-4459-b68e-87a9e22241f0
Evans, D.G.R.
2fd1ea41-abdf-4d13-a2a3-afa9ba2f4c12

Foster, C., Watson, M., Eeles, R., Eccles, D., Ashley, S., Davidson, R., Mackay, J., Morrison, P.J., Hopwood, P. and Evans, D.G.R. , Psychosocial Study Collaborators (2007) Predictive genetic testing for BRCA1/2 in a UK clinical cohort: three-year follow-up. British Journal of Cancer, 96 (5), 718-724. (doi:10.1038/sj.bjc.6603610).

Record type: Article

Abstract

This prospective multicentre study assesses long-term impact of genetic testing for breast/ovarian cancer predisposition in a clinical cohort. Areas evaluated include risk management, distress and insurance problems 3 years post-testing. Participants are adults unaffected with cancer from families with a known BRCA1/2 mutation. One hundred and ninety-three out of 285 (70% response) participants at nine UK clinical genetics centres completed assessments at 3 years: 80% female; 37% carriers of a BRCA1/2 mutation. In the 3 years, post-genetic testing carriers reported more risk management activities than non-carriers. Fifty-five per cent of female carriers opted for risk reducing surgery; 43% oophorectomy; and 34% mastectomy. Eighty-nine per cent had mammograms compared with 47% non-carriers. Thirty-six per cent non-carriers >= 50 years did not have a mammogram post-test. Twenty-two per cent male carriers had colorectal and 44% prostate screening compared with 5 and 19% non-carriers respectively. Seven per cent carriers and 1% non-carriers developed cancer. Distress levels did not differ in carriers and non- carriers at 3-year follow-up. Forty per cent of female carriers reported difficulties with life and/or health insurance. Given the return to pre-test levels of concern among female non- carriers at 3 years and a substantial minority not engaging in recommended screening, there appears to be a need to help some women understand the meaning of their genetic status

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More information

Published date: 6 February 2007
Keywords: genetic testing, risk management, psychological, BRCA1/2
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 62743
URI: http://eprints.soton.ac.uk/id/eprint/62743
ISSN: 0007-0920
PURE UUID: e982a4bf-5f7d-4915-8190-15853d9049f2
ORCID for C. Foster: ORCID iD orcid.org/0000-0002-4703-8378

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Date deposited: 04 Sep 2008
Last modified: 03 Dec 2019 01:48

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Contributors

Author: C. Foster ORCID iD
Author: M. Watson
Author: R. Eeles
Author: D. Eccles
Author: S. Ashley
Author: R. Davidson
Author: J. Mackay
Author: P.J. Morrison
Author: P. Hopwood
Author: D.G.R. Evans

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