Prognostic markers in chronic lympocytic leukaemia
Prognostic markers in chronic lympocytic leukaemia
Rai and Binet staging of chronic lymphocytic leukaemia (CLL) is being superseded by new prognostic markers. The mutational status of the immunoglobulin variable region heavy-chain genes segregates the disease into more benign and more malignant versions, and has been confirmed as an important prognostic marker in prospective clinical trials. A search for surrogate markers for this difficult-to-perform assay has led to flow cytometric assays for CD38 and ZAP-70 expression, although in both cases there are problems with standardization and interpretation of the assays. A separate pathway of research has revealed two chromosomal aberrations deletions of 11q and 17p - as important prognostic markers. Fluorescent in-situ hybridization has made their detection readily available. These five markers are in different stages of evaluation, but some of them are ready to be used for risk-adapted therapy in clinical trials. Other assays are in earlier stages of assessment.
time, high-risk, heavy-chain gene, igv(h) genes, gene, cd38, binet, expression, cll, cd38 expression, genomic aberrations, chronic lymphocytic-leukemia, del 17p, disease, variable-region mutations
455-468
Hamblin, Terry J.
57389613-7900-48fd-b3e6-8ca8fbdceccb
September 2007
Hamblin, Terry J.
57389613-7900-48fd-b3e6-8ca8fbdceccb
Hamblin, Terry J.
(2007)
Prognostic markers in chronic lympocytic leukaemia.
Best Practice and Research Clinical Haematology, 20 (3), .
(doi:10.1016/j.beha.2007.02.001).
Abstract
Rai and Binet staging of chronic lymphocytic leukaemia (CLL) is being superseded by new prognostic markers. The mutational status of the immunoglobulin variable region heavy-chain genes segregates the disease into more benign and more malignant versions, and has been confirmed as an important prognostic marker in prospective clinical trials. A search for surrogate markers for this difficult-to-perform assay has led to flow cytometric assays for CD38 and ZAP-70 expression, although in both cases there are problems with standardization and interpretation of the assays. A separate pathway of research has revealed two chromosomal aberrations deletions of 11q and 17p - as important prognostic markers. Fluorescent in-situ hybridization has made their detection readily available. These five markers are in different stages of evaluation, but some of them are ready to be used for risk-adapted therapy in clinical trials. Other assays are in earlier stages of assessment.
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Published date: September 2007
Keywords:
time, high-risk, heavy-chain gene, igv(h) genes, gene, cd38, binet, expression, cll, cd38 expression, genomic aberrations, chronic lymphocytic-leukemia, del 17p, disease, variable-region mutations
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Local EPrints ID: 62772
URI: http://eprints.soton.ac.uk/id/eprint/62772
ISSN: 1521-6926
PURE UUID: f41939f2-d3da-4a80-a551-65cb0cd6eaed
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Date deposited: 11 Sep 2008
Last modified: 15 Mar 2024 11:32
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Author:
Terry J. Hamblin
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