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Evidence for a colorectal cancer susceptibility locus on chromosome 3q21-q24 from a high-density SNP genome-wide linkage scan

Evidence for a colorectal cancer susceptibility locus on chromosome 3q21-q24 from a high-density SNP genome-wide linkage scan
Evidence for a colorectal cancer susceptibility locus on chromosome 3q21-q24 from a high-density SNP genome-wide linkage scan
To identify a novel susceptibility gene for colorectal cancer (CRC), we conducted a genome-wide linkage analysis of 69 pedigrees segregating colorectal neoplasia in which involvement of known loci had been excluded, using a high-density single nucleotide polymorphism (SNP) array containing 10 204 markers. Multipoint linkage analyses were undertaken using both non-parametric (model-free) and parametric (model-based) methods. After the removal of SNPs in strong linkage disequilibrium, we obtained a maximum non-parametric linkage statistic of 3.40 (P=0.0003) at chromosomal region 3q21-q24. The same genomic position also yielded the highest multipoint heterogeneity LOD (HLOD) score under a dominant model (HLOD=3.10, genome-wide P=0.038) with 62% of families linked to the locus. We provide evidence for a novel CRC susceptibility gene. Further studies are needed to confirm this localization and to evaluate the contribution of this locus to disease incidence
locus, colonoscopy, cancer susceptibility, risk, susceptibility, scan, time, guidelines, disease, disequilibrium, history, families, array, kindreds, maps, women, colorectal cancer, model, involvement, surveillance, single, colorectal-cancer, region, single nucleotide polymorphism, cancer, gene, polypectomy
2903-2910
Kemp, Z.
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Carvajal-Carmona, L.
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Spain, S.
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Barclay, E.
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Gorman, M.
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Martin, L.
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Jaeger, E.
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Brooks, N.
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Bishop, D.T.
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Thomas, H.
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Tomlinson, I.
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Papaemmanuil, E.
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Webb, E.
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Sellick, G.S.
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Wood, W.
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Evans, G.
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Lucassen, A.
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Maher, E.R.
cbc3d987-e63b-4f47-b19c-4efd77487c2e
Houlston, R.S.
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Kemp, Z.
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Carvajal-Carmona, L.
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Spain, S.
867ba0da-2cc6-4f73-b3ef-a888912f4542
Barclay, E.
172cafc3-e9ef-4c7a-a164-897d4c632856
Gorman, M.
315c0d2e-3998-4712-9bb8-d802a76a21fa
Martin, L.
8da71992-a039-4238-9297-879407850743
Jaeger, E.
0c265fdf-e2e3-4d22-a2ea-b2ea345ee1d8
Brooks, N.
2b13f624-ea4b-4b79-a8fc-3d974cca79b4
Bishop, D.T.
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Thomas, H.
6482f172-19a3-4f91-a2e4-f6b1cd55ccdd
Tomlinson, I.
5e8c5461-1b79-42f8-b0ab-14453f114efb
Papaemmanuil, E.
4cf00970-7c24-424d-8df1-1a28194610a0
Webb, E.
0be041fb-36ab-4e02-836d-ec0bc4162031
Sellick, G.S.
d0bb11c1-7305-4dd9-8864-4ba69d985b9c
Wood, W.
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Evans, G.
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Lucassen, A.
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Maher, E.R.
cbc3d987-e63b-4f47-b19c-4efd77487c2e
Houlston, R.S.
513f47bc-c527-47d5-847d-20482ab5d583

Kemp, Z., Carvajal-Carmona, L., Spain, S., Barclay, E., Gorman, M., Martin, L., Jaeger, E., Brooks, N., Bishop, D.T., Thomas, H., Tomlinson, I., Papaemmanuil, E., Webb, E., Sellick, G.S., Wood, W., Evans, G., Lucassen, A., Maher, E.R. and Houlston, R.S. (2006) Evidence for a colorectal cancer susceptibility locus on chromosome 3q21-q24 from a high-density SNP genome-wide linkage scan. Human Molecular Genetics, 15 (19), 2903-2910.

Record type: Article

Abstract

To identify a novel susceptibility gene for colorectal cancer (CRC), we conducted a genome-wide linkage analysis of 69 pedigrees segregating colorectal neoplasia in which involvement of known loci had been excluded, using a high-density single nucleotide polymorphism (SNP) array containing 10 204 markers. Multipoint linkage analyses were undertaken using both non-parametric (model-free) and parametric (model-based) methods. After the removal of SNPs in strong linkage disequilibrium, we obtained a maximum non-parametric linkage statistic of 3.40 (P=0.0003) at chromosomal region 3q21-q24. The same genomic position also yielded the highest multipoint heterogeneity LOD (HLOD) score under a dominant model (HLOD=3.10, genome-wide P=0.038) with 62% of families linked to the locus. We provide evidence for a novel CRC susceptibility gene. Further studies are needed to confirm this localization and to evaluate the contribution of this locus to disease incidence

Full text not available from this repository.

More information

Published date: 2006
Keywords: locus, colonoscopy, cancer susceptibility, risk, susceptibility, scan, time, guidelines, disease, disequilibrium, history, families, array, kindreds, maps, women, colorectal cancer, model, involvement, surveillance, single, colorectal-cancer, region, single nucleotide polymorphism, cancer, gene, polypectomy

Identifiers

Local EPrints ID: 62814
URI: http://eprints.soton.ac.uk/id/eprint/62814
PURE UUID: bf562f1d-de89-4f46-baa1-5f5dd3c3c7f2

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Date deposited: 11 Sep 2008
Last modified: 13 Mar 2019 20:27

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Contributors

Author: Z. Kemp
Author: L. Carvajal-Carmona
Author: S. Spain
Author: E. Barclay
Author: M. Gorman
Author: L. Martin
Author: E. Jaeger
Author: N. Brooks
Author: D.T. Bishop
Author: H. Thomas
Author: I. Tomlinson
Author: E. Papaemmanuil
Author: E. Webb
Author: G.S. Sellick
Author: W. Wood
Author: G. Evans
Author: A. Lucassen
Author: E.R. Maher
Author: R.S. Houlston

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