The University of Southampton
University of Southampton Institutional Repository

Immunostimulatory monoclonal antibodies for cancer therapy

Record type: Article

Increasing immune responses with immunostimulatory monoclonal antibodies (mAbs) directed to immune-receptor molecules is a new and exciting strategy in cancer therapy. This expanding class of agents functions on crucial receptors, either antagonizing those that suppress immune responses or activating others that amplify immune responses. Complications such as autoimmunity and systemic inflammation are problematic side effects associated with these agents. However, promising synergy has been observed in preclinical models using combinations of immunostimulatory antibodies and other immunotherapy strategies or conventional cancer therapies. Importantly, mAbs of this type have now entered clinical trials with encouraging initial results

Full text not available from this repository.

Citation

Melero, Ignatio, Hervas-Stubbs, Sandra, Glennie, Martin, Pardoll, Drew M. and Chen, Lieping P. (2007) Immunostimulatory monoclonal antibodies for cancer therapy Nature Reviews Cancer, 7, (2), pp. 95-106. (doi:10.1038/nrc2051).

More information

Published date: February 2007
Keywords: time, versus-host-disease, cancer, molecules, antigen-4 blockade, immune-responses, model, dendritic cells, phase-i trial, gene-therapy, immunotherapy, enhances antitumor immunity, monoclonal antibody, regulatory t-cells, responses, 4-1bb ligand, models, ctla-4 blockade, monoclonal-antibodies, metastatic melanoma

Identifiers

Local EPrints ID: 62840
URI: http://eprints.soton.ac.uk/id/eprint/62840
ISSN: 1474-175X
PURE UUID: 19f3d18a-dad1-41f6-84f8-0a0c66a98e56

Catalogue record

Date deposited: 11 Sep 2008
Last modified: 17 Jul 2017 14:19

Export record

Altmetrics

Contributors

Author: Ignatio Melero
Author: Sandra Hervas-Stubbs
Author: Martin Glennie
Author: Drew M. Pardoll
Author: Lieping P. Chen

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×