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Immunostimulatory monoclonal antibodies for cancer therapy

Melero, Ignatio, Hervas-Stubbs, Sandra, Glennie, Martin, Pardoll, Drew M. and Chen, Lieping P. (2007) Immunostimulatory monoclonal antibodies for cancer therapy Nature Reviews Cancer, 7, (2), pp. 95-106. (doi:10.1038/nrc2051).

Record type: Article


Increasing immune responses with immunostimulatory monoclonal antibodies (mAbs) directed to immune-receptor molecules is a new and exciting strategy in cancer therapy. This expanding class of agents functions on crucial receptors, either antagonizing those that suppress immune responses or activating others that amplify immune responses. Complications such as autoimmunity and systemic inflammation are problematic side effects associated with these agents. However, promising synergy has been observed in preclinical models using combinations of immunostimulatory antibodies and other immunotherapy strategies or conventional cancer therapies. Importantly, mAbs of this type have now entered clinical trials with encouraging initial results

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Published date: February 2007
Keywords: time, versus-host-disease, cancer, molecules, antigen-4 blockade, immune-responses, model, dendritic cells, phase-i trial, gene-therapy, immunotherapy, enhances antitumor immunity, monoclonal antibody, regulatory t-cells, responses, 4-1bb ligand, models, ctla-4 blockade, monoclonal-antibodies, metastatic melanoma


Local EPrints ID: 62840
ISSN: 1474-175X
PURE UUID: 19f3d18a-dad1-41f6-84f8-0a0c66a98e56

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Date deposited: 11 Sep 2008
Last modified: 17 Jul 2017 14:19

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Author: Ignatio Melero
Author: Sandra Hervas-Stubbs
Author: Martin Glennie
Author: Drew M. Pardoll
Author: Lieping P. Chen

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