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The combination of raltitrexed (Tomudex) and mitomycin-C in the treatment of advanced colorectal cancer - A phase II study

The combination of raltitrexed (Tomudex) and mitomycin-C in the treatment of advanced colorectal cancer - A phase II study
The combination of raltitrexed (Tomudex) and mitomycin-C in the treatment of advanced colorectal cancer - A phase II study
Aims To investigate the combination of raltitrexed and mitomycin-C as first-line chemotherapy treatment in patients with advanced colorectal cancer.
Materials and methods A phase II study.
Results In total, 22 patients were treated with a combination of raltitrexed 3 mg/m2 every 3 weeks and mitomycin-C 7 mg/m2 every 6 weeks for up to 24 weeks. The study was closed early for safety reasons as there were three unexpected treatment-related deaths. The overall response rate was 20%, and a further 40% achieved stable disease. The median time to progression was 3.9 months and the median overall survival time was 11.6 months.
Conclusion Owing to the potential for increased toxicity, the combination of raltitrexed and mitomycin-C cannot be recommended as first-line treatment in patients with advanced colorectal cancer.
disease, advanced colorectal cancer, oxaliplatin, cancer, survival, raltitrexed, fluorouracil, colorectal-cancer, mitomycin-c, death, chemotherapy, 1st-line treatment, 5-fluorouracil, irinotecan
0936-6555
431-435
Michels, J.
01124646-b096-4cec-86c9-2cbddaad8e74
Geldart, T.
829fdbee-84dd-4825-b5eb-0e6e859ba9ff
Darby, A.
40e52ac7-914f-4fbc-b5d1-29912b81573b
Craddock, L.
4a465daa-acd0-41b1-a291-535e5addd338
Iveson, A.
0ab65b72-7381-41e1-a01a-a8513fa1f0aa
Richardson, L.
500946e3-bcc9-4dd3-950d-9a8f2e09c314
Iveson, T.
867cb6c5-ea9a-4521-a4cc-4cd4d2503b3a
Michels, J.
01124646-b096-4cec-86c9-2cbddaad8e74
Geldart, T.
829fdbee-84dd-4825-b5eb-0e6e859ba9ff
Darby, A.
40e52ac7-914f-4fbc-b5d1-29912b81573b
Craddock, L.
4a465daa-acd0-41b1-a291-535e5addd338
Iveson, A.
0ab65b72-7381-41e1-a01a-a8513fa1f0aa
Richardson, L.
500946e3-bcc9-4dd3-950d-9a8f2e09c314
Iveson, T.
867cb6c5-ea9a-4521-a4cc-4cd4d2503b3a

Michels, J., Geldart, T., Darby, A., Craddock, L., Iveson, A., Richardson, L. and Iveson, T. (2006) The combination of raltitrexed (Tomudex) and mitomycin-C in the treatment of advanced colorectal cancer - A phase II study. Clinical Oncology, 18 (6), 431-435. (doi:10.1016/j.clon.2006.01.003).

Record type: Article

Abstract

Aims To investigate the combination of raltitrexed and mitomycin-C as first-line chemotherapy treatment in patients with advanced colorectal cancer.
Materials and methods A phase II study.
Results In total, 22 patients were treated with a combination of raltitrexed 3 mg/m2 every 3 weeks and mitomycin-C 7 mg/m2 every 6 weeks for up to 24 weeks. The study was closed early for safety reasons as there were three unexpected treatment-related deaths. The overall response rate was 20%, and a further 40% achieved stable disease. The median time to progression was 3.9 months and the median overall survival time was 11.6 months.
Conclusion Owing to the potential for increased toxicity, the combination of raltitrexed and mitomycin-C cannot be recommended as first-line treatment in patients with advanced colorectal cancer.

Full text not available from this repository.

More information

Published date: August 2006
Keywords: disease, advanced colorectal cancer, oxaliplatin, cancer, survival, raltitrexed, fluorouracil, colorectal-cancer, mitomycin-c, death, chemotherapy, 1st-line treatment, 5-fluorouracil, irinotecan

Identifiers

Local EPrints ID: 62843
URI: http://eprints.soton.ac.uk/id/eprint/62843
ISSN: 0936-6555
PURE UUID: 9488415b-a11c-4bb1-96da-5630f6a30fc9

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Date deposited: 11 Sep 2008
Last modified: 13 Mar 2019 20:27

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