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Mammographic density and breast cancer risk in BRCA1 and BRCA2 mutation carriers

Mammographic density and breast cancer risk in BRCA1 and BRCA2 mutation carriers
Mammographic density and breast cancer risk in BRCA1 and BRCA2 mutation carriers
High breast density as measured on mammograms is a strong risk factor for breast cancer in the general population, but its effect in carriers of germline BRCA1 and BRCA2 mutations is unclear. We obtained mammograms from 206 female carriers of BRCA1 or BRCA2 mutations, 96 of whom were subsequently diagnosed with breast cancer and 136 relatives of carriers who were themselves noncarriers. We compared the mammographic densities of affected carriers (cases) and unaffected carriers (controls), and of mutation carriers and noncarriers, using a computer-assisted method of measurement and visual assessment by two observers. Analyses were adjusted for age, parity, body mass index, menopausal status, and hormone replacement therapy use. There was no difference in the mean percent density between noncarriers and carriers. Among carriers, increasing mammographic density was associated with an increased risk of breast cancer (P-trend = 0.024). The odds ratio (OR; 95% confidence interval) for breast cancer associated with a density of >= 50% was 2.29 (1.23-4.26; P = 0.009). The OR did not differ between BRCA1 and BRCA2 carriers or between premenopausal and postmenopausal carriers. The results suggest that the distribution of breast density in BRCA1 and BRCA2 carriers is similar to that in noncarriers. High breast density in carriers is associated with an increased risk of breast cancer, with the relative risk being similar to that observed in the general population. Use of mammographic density could improve individual risk prediction in carriers
disease, mutations, age, united-states, breast, brca1, mutation carriers, risk, parenchymal patterns, time, diet, women, mutation, breast-cancer, cancer, family-history, tissue, prediction, carcinoma, brca2 mutations, breast cancer, features, brca2
0008-5472
1866-1872
Mitchell, Gillian
5091b5ee-dac1-4a68-8b4f-9ec2dbc198e4
Antoniou, Antonis C.
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Warren, Ruth
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Peock, Susan
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Brown, Judith
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Davies, Russell
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Mattison, Jenny
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Cook, Margaret
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Warsi, Iqbal
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Evans, D. Gareth
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Eccles, Diana
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Douglas, Fiona
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Paterson, Joan
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Hodgson, Shirley
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Izatt, Louise
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Cole, Trevor
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Burgess, Lucy
368644bc-e9b4-4c57-8b88-d0ecc4f52c5c
Eeles, Ros
1101f5dc-f8ae-4102-99fb-f814695e5f9c
Easton, Douglas F.
2661cf5e-8fc6-4f1d-b27a-e60cac8c8819
Mitchell, Gillian
5091b5ee-dac1-4a68-8b4f-9ec2dbc198e4
Antoniou, Antonis C.
b5275276-df7e-42a4-9a38-6a9516924f0d
Warren, Ruth
2ba49c5b-5a61-447f-9fbb-820e92c60bff
Peock, Susan
7e420471-9ee5-4a07-9536-bfdc4c6f1297
Brown, Judith
0fbc2e9c-632b-43af-9b0f-40b57327b617
Davies, Russell
d2b3f4f7-4387-4b28-bd02-dedc22c38b7b
Mattison, Jenny
5368dc42-4452-4a81-80a9-f72e00cfde90
Cook, Margaret
b693d851-afb5-4cf6-ad02-4bb9169b5fe3
Warsi, Iqbal
e2757427-e784-4420-8abd-cd9f167cc08a
Evans, D. Gareth
314acefb-89fb-4eb7-a0e7-0a6949c9af6c
Eccles, Diana
5b59bc73-11c9-4cf0-a9d5-7a8e523eee23
Douglas, Fiona
a35f2e38-4fc4-481e-a212-1e3ae5d5ae0c
Paterson, Joan
79204243-74c8-46f7-881b-091043581334
Hodgson, Shirley
a9f6b2c4-f329-40b5-8b07-a74b3fdd1a0c
Izatt, Louise
5d6201a8-8a56-4923-ac9d-75dca6be0a40
Cole, Trevor
5d7a1e62-1c71-4b07-acdd-652f08f153d4
Burgess, Lucy
368644bc-e9b4-4c57-8b88-d0ecc4f52c5c
Eeles, Ros
1101f5dc-f8ae-4102-99fb-f814695e5f9c
Easton, Douglas F.
2661cf5e-8fc6-4f1d-b27a-e60cac8c8819

Mitchell, Gillian, Antoniou, Antonis C., Warren, Ruth, Peock, Susan, Brown, Judith, Davies, Russell, Mattison, Jenny, Cook, Margaret, Warsi, Iqbal, Evans, D. Gareth, Eccles, Diana, Douglas, Fiona, Paterson, Joan, Hodgson, Shirley, Izatt, Louise, Cole, Trevor, Burgess, Lucy, Eeles, Ros and Easton, Douglas F. (2006) Mammographic density and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Cancer Research, 66 (3), 1866-1872.

Record type: Article

Abstract

High breast density as measured on mammograms is a strong risk factor for breast cancer in the general population, but its effect in carriers of germline BRCA1 and BRCA2 mutations is unclear. We obtained mammograms from 206 female carriers of BRCA1 or BRCA2 mutations, 96 of whom were subsequently diagnosed with breast cancer and 136 relatives of carriers who were themselves noncarriers. We compared the mammographic densities of affected carriers (cases) and unaffected carriers (controls), and of mutation carriers and noncarriers, using a computer-assisted method of measurement and visual assessment by two observers. Analyses were adjusted for age, parity, body mass index, menopausal status, and hormone replacement therapy use. There was no difference in the mean percent density between noncarriers and carriers. Among carriers, increasing mammographic density was associated with an increased risk of breast cancer (P-trend = 0.024). The odds ratio (OR; 95% confidence interval) for breast cancer associated with a density of >= 50% was 2.29 (1.23-4.26; P = 0.009). The OR did not differ between BRCA1 and BRCA2 carriers or between premenopausal and postmenopausal carriers. The results suggest that the distribution of breast density in BRCA1 and BRCA2 carriers is similar to that in noncarriers. High breast density in carriers is associated with an increased risk of breast cancer, with the relative risk being similar to that observed in the general population. Use of mammographic density could improve individual risk prediction in carriers

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More information

Published date: 1 February 2006
Keywords: disease, mutations, age, united-states, breast, brca1, mutation carriers, risk, parenchymal patterns, time, diet, women, mutation, breast-cancer, cancer, family-history, tissue, prediction, carcinoma, brca2 mutations, breast cancer, features, brca2

Identifiers

Local EPrints ID: 62848
URI: http://eprints.soton.ac.uk/id/eprint/62848
ISSN: 0008-5472
PURE UUID: a1f65c42-7b91-4f17-803f-c4c2a9ea74a7

Catalogue record

Date deposited: 04 Sep 2008
Last modified: 13 Mar 2019 20:27

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Contributors

Author: Gillian Mitchell
Author: Antonis C. Antoniou
Author: Ruth Warren
Author: Susan Peock
Author: Judith Brown
Author: Russell Davies
Author: Jenny Mattison
Author: Margaret Cook
Author: Iqbal Warsi
Author: D. Gareth Evans
Author: Diana Eccles
Author: Fiona Douglas
Author: Joan Paterson
Author: Shirley Hodgson
Author: Louise Izatt
Author: Trevor Cole
Author: Lucy Burgess
Author: Ros Eeles
Author: Douglas F. Easton

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