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MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom)

MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom)
MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom)
Objective The purpose of this study was to further evaluate the role of low activity MTHFR variants as well as to explore interactive effects between alcoholic drink consumption and MTHFR variants and risk of distal colorectal adenomatous polyps.
Methods We examined the relationship between MTHFR C677T and A1298C gene polymorphisms and risk of distal adenomas in one of the largest case control studies of 946 polyp-free controls and 894 cases, all participants of the UK Flexible Sigmoidoscopy Screening Trial (UKFSS).
Results Investigation of the effect of the MTHFR C677T polymorphism in this large UKFSS study revealed no overall association on adenoma risk (P > 0.05). However the MTHFR 1298C allele was linked, for the first time, to high risk adenomas, although in males only (odds ratio (OR) for A/C+C/C compared with A/A 1.55; 95% confidence interval (CI), 1.08-2.22; P=0.018).
Conclusions In this, the largest study of these polymorphisms in relation to colorectal adenoma, there was no evidence for an interaction with alcohol in combination with the variant forms of MTHFR (P > 0.05)
combination, gene, sigmoidoscopy, high-risk, trial, methylenetetrahydrofolate reductase gene, folate, common mutation, colon-cancer, care, variant, uk flexible sigmoidoscopy screening trial
0957-5243
793-801
Mitrou, Panagiota N.
af30d670-36ed-44ef-8f7b-89bcbca04616
Watson, Mark A.
48aea4a8-00cb-441b-b090-b4350b00a98d
Loktionov, Alexandre S.
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Cardwell, Christopher
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Gunter, Marc J.
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Atkin, Wendy S.
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Macklin, Christopher P.
be3a7fe0-c3ed-421e-b50a-02c6e023a53f
Cecil, Tom
fff8d82e-2019-402f-a931-1c9591ffc133
Bishop, Timothy D.
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Primrose, John
d85f3b28-24c6-475f-955b-ec457a3f9185
Bingham, Sheila A.
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Mitrou, Panagiota N.
af30d670-36ed-44ef-8f7b-89bcbca04616
Watson, Mark A.
48aea4a8-00cb-441b-b090-b4350b00a98d
Loktionov, Alexandre S.
bef20815-afc2-4a37-bf24-b435d161552f
Cardwell, Christopher
11595aee-491e-4da2-a906-65399fa10732
Gunter, Marc J.
8dde34f9-71b3-4f43-a3bb-f53e0c135154
Atkin, Wendy S.
9bd5a0aa-dbcb-4709-8ec1-a65f110062a7
Macklin, Christopher P.
be3a7fe0-c3ed-421e-b50a-02c6e023a53f
Cecil, Tom
fff8d82e-2019-402f-a931-1c9591ffc133
Bishop, Timothy D.
0b8e307a-d30e-4402-917d-9db867f694a1
Primrose, John
d85f3b28-24c6-475f-955b-ec457a3f9185
Bingham, Sheila A.
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Mitrou, Panagiota N., Watson, Mark A., Loktionov, Alexandre S., Cardwell, Christopher, Gunter, Marc J., Atkin, Wendy S., Macklin, Christopher P., Cecil, Tom, Bishop, Timothy D., Primrose, John and Bingham, Sheila A. (2006) MTHFR (C677T and A1298C) polymorphisms and risk of sporadic distal colorectal adenoma in the UK Flexible Sigmoidoscopy Screening Trial (United Kingdom). Cancer Causes & Control, 17 (6), 793-801. (doi:10.1007/s10552-006-0016-8).

Record type: Article

Abstract

Objective The purpose of this study was to further evaluate the role of low activity MTHFR variants as well as to explore interactive effects between alcoholic drink consumption and MTHFR variants and risk of distal colorectal adenomatous polyps.
Methods We examined the relationship between MTHFR C677T and A1298C gene polymorphisms and risk of distal adenomas in one of the largest case control studies of 946 polyp-free controls and 894 cases, all participants of the UK Flexible Sigmoidoscopy Screening Trial (UKFSS).
Results Investigation of the effect of the MTHFR C677T polymorphism in this large UKFSS study revealed no overall association on adenoma risk (P > 0.05). However the MTHFR 1298C allele was linked, for the first time, to high risk adenomas, although in males only (odds ratio (OR) for A/C+C/C compared with A/A 1.55; 95% confidence interval (CI), 1.08-2.22; P=0.018).
Conclusions In this, the largest study of these polymorphisms in relation to colorectal adenoma, there was no evidence for an interaction with alcohol in combination with the variant forms of MTHFR (P > 0.05)

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Published date: August 2006
Keywords: combination, gene, sigmoidoscopy, high-risk, trial, methylenetetrahydrofolate reductase gene, folate, common mutation, colon-cancer, care, variant, uk flexible sigmoidoscopy screening trial

Identifiers

Local EPrints ID: 62849
URI: http://eprints.soton.ac.uk/id/eprint/62849
ISSN: 0957-5243
PURE UUID: 52215698-73f8-4eb4-a22c-321f2a8328f0
ORCID for John Primrose: ORCID iD orcid.org/0000-0002-2069-7605

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Date deposited: 11 Sep 2008
Last modified: 20 Jul 2019 01:19

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Contributors

Author: Panagiota N. Mitrou
Author: Mark A. Watson
Author: Alexandre S. Loktionov
Author: Christopher Cardwell
Author: Marc J. Gunter
Author: Wendy S. Atkin
Author: Christopher P. Macklin
Author: Tom Cecil
Author: Timothy D. Bishop
Author: John Primrose ORCID iD
Author: Sheila A. Bingham

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