Mo, Y., Sheppard, S.V. and Smith, D.C.
The influence of mannitol on the volume of fluid given to adult patients during cardiopulmonary bypass
Anaesthesia, 62, (11), . (doi:10.1111/j.1365-2044.2007.05344.x).
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During cardiopulmonary bypass, non-blood fluids are
added to the circulation via the priming of the circuit.
There is no standardisation of priming fluids between different cardiac centres, but most use a mixture of crystalloid and colloid. Mannitol, an osmotic diuretic, is often used in the prime with the aim of minimising renal damage. Although mannitol has no effect on renal function we have noticed that it reduces the amount of additional fluid given to maintain reservoir volume. This study aims at examining the effects of mannitol on fluid balance during cardiopulmonary bypass.
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