Molecular machinations of the MHC-I peptide loading complex

Purcell, A.W. and Elliott, T. (2008) Molecular machinations of the MHC-I peptide loading complex Current Opinion in Immunology, 20, (1), pp. 75-81.


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The acquisition of an optimal peptide ligand by MHC class I molecules is crucial for the generation of immunity to viruses and tumors. This process is orchestrated by a molecular machine known as the peptide loading complex (PLC) that consists of specialized and general ER-resident molecules. These proteins collaborate to ensure the loading of an optimal peptide ligand into the antigen binding cleft of class I molecules. The surprising diversity of peptides bound to MHC class I molecules and recapitulation of class I assembly in vitro have provided new insights into the molecular machinations of peptide loading. Coupled with the extraordinary polymorphism of class I molecules and their differential dependence on various components of the PLC for cell surface expression, a picture of peptide loading at the molecular level has recently emerged and will be discussed herein

Item Type: Article
ISSNs: 0952-7915 (print)
Related URLs:
Keywords: antigen, cell, endoplasmic-reticulum, expression, t-cell recognition, tapasin, time, protein, surface expression, erp57, in-vitro, tap, alpha-2 domain, antigen presentation, binding, immunity, absence, tumors
Subjects: R Medicine
ePrint ID: 62885
Date :
Date Event
Date Deposited: 10 Sep 2008
Last Modified: 16 Apr 2017 17:28
Further Information:Google Scholar

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