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Molecular machinations of the MHC-I peptide loading complex

Record type: Article

The acquisition of an optimal peptide ligand by MHC class I molecules is crucial for the generation of immunity to viruses and tumors. This process is orchestrated by a molecular machine known as the peptide loading complex (PLC) that consists of specialized and general ER-resident molecules. These proteins collaborate to ensure the loading of an optimal peptide ligand into the antigen binding cleft of class I molecules. The surprising diversity of peptides bound to MHC class I molecules and recapitulation of class I assembly in vitro have provided new insights into the molecular machinations of peptide loading. Coupled with the extraordinary polymorphism of class I molecules and their differential dependence on various components of the PLC for cell surface expression, a picture of peptide loading at the molecular level has recently emerged and will be discussed herein

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Purcell, A.W. and Elliott, T. (2008) Molecular machinations of the MHC-I peptide loading complex Current Opinion in Immunology, 20, (1), pp. 75-81.

More information

Published date: 2008
Keywords: antigen, cell, endoplasmic-reticulum, expression, t-cell recognition, tapasin, time, protein, surface expression, erp57, in-vitro, tap, alpha-2 domain, antigen presentation, binding, immunity, absence, tumors


Local EPrints ID: 62885
ISSN: 0952-7915
PURE UUID: 82f93b6b-420a-4c60-8eb4-cfb629645867
ORCID for T. Elliott: ORCID iD

Catalogue record

Date deposited: 10 Sep 2008
Last modified: 17 Jul 2017 14:19

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