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Quality of life assessment in advanced pancreatic adenocarcinoma: Results from a phase III Randomized trial

Reni, M., Bonetto, E., Cordio, S., Passoni, P., Milandri, C., Cereda, S., Spreafico, A., Galli, L., Bordonaro, R., Staudacher, C., Di Carlo, V. and Johnson, C.D. (2006) Quality of life assessment in advanced pancreatic adenocarcinoma: Results from a phase III Randomized trial Pancreatology, 6, (5), pp. 454-463. (doi:10.1159/000094563).

Record type: Article


Background: A phase III trial suggested that a PEFG ( cisplatin, epirubicin, 5-fluorouracil, gemcitabine) regimen might improve the outcome compared to gemcitabine in advanced pancreatic adenocarcinoma. The analysis of treatment impact on quality of life (QOL) is reported.
Method: Patients completed the European Organization for Research and Treatment of Cancer QLQ-C30 and PAN-26 questionnaires at baseline and every second month of treatment until disease progression.
Results: The largest differences between arms favored PEFG. Expressed as improvement 6 10 points from baseline (PEFG/gemcitabine), these were: emotional function (43/18%), fatigue (41/17%), QOL (55/29%), pain (64/41%), and flatulence (50/26%). Only change in sexual function favored gemcitabine (19/42%). Physical function, fatigue, appetite, and satisfaction with healthcare improved in 40 - 46% of partial responders compared with 0 - 12% of patients with stable disease.
Conclusion: Clinically relevant improvement in QOL from baseline was observed more often after PEFG than after gemcitabine, suggesting that the PEFG regimen did not impair QOL, Partial response was associated with improved QOL suggesting that effective treatment of pancreatic adenocarcinoma may have an important role in these patients.

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Published date: 2006
Keywords: plus, European-organization, qlq-c30, time, phase-iii, patient, quality-of-life, adenocarcinoma, disease progression, disease, single-agent, cisplatin, cancer, clinical benefit, pain, chemotherapy, trial, carcinoma, mitomycin, epirubicin, quality of life, phase iii trial, gemcitabine, randomized-trial, 5-fluorouracil, pancreatic cancer, survival, pefg regimen, regimen, fluorouracil


Local EPrints ID: 62893
ISSN: 1424-3903
PURE UUID: 193b9524-d11b-40e8-bf23-ba937b2880fe

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Date deposited: 09 Sep 2008
Last modified: 17 Jul 2017 14:19

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Author: M. Reni
Author: E. Bonetto
Author: S. Cordio
Author: P. Passoni
Author: C. Milandri
Author: S. Cereda
Author: A. Spreafico
Author: L. Galli
Author: R. Bordonaro
Author: C. Staudacher
Author: V. Di Carlo
Author: C.D. Johnson

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