Management of advanced colorectal cancer: state of the art
Management of advanced colorectal cancer: state of the art
Colorectal cancer ( CRC) caused over 500 000 deaths worldwide in 2002. Recent advances in the treatment of advanced disease include the incorporation of two new cytotoxic agents, irinotecan and oxaliplatin, into first- line regimens. The concept of planned sequential therapy involving three active agents during the course of a patient's treatment is evolving. Coupled with the integrated use of targeted monoclonal antibodies, we can now expect overall survival rates for advanced disease to exceed 20 months. This review considers current treatments and suggests where future progress may occur
colorectal cancer, first-line, 5-fluorouracil, irinotecan, oxaliplatin, targeted agents
131-138
Saunders, M.
cd8bb634-404f-4a0c-b7e0-dfe855bb3312
Iveson, T.
867cb6c5-ea9a-4521-a4cc-4cd4d2503b3a
2006
Saunders, M.
cd8bb634-404f-4a0c-b7e0-dfe855bb3312
Iveson, T.
867cb6c5-ea9a-4521-a4cc-4cd4d2503b3a
Saunders, M. and Iveson, T.
(2006)
Management of advanced colorectal cancer: state of the art.
British Journal of Cancer, 95 (2), .
(doi:10.1038/sj.bjc.6603233).
Abstract
Colorectal cancer ( CRC) caused over 500 000 deaths worldwide in 2002. Recent advances in the treatment of advanced disease include the incorporation of two new cytotoxic agents, irinotecan and oxaliplatin, into first- line regimens. The concept of planned sequential therapy involving three active agents during the course of a patient's treatment is evolving. Coupled with the integrated use of targeted monoclonal antibodies, we can now expect overall survival rates for advanced disease to exceed 20 months. This review considers current treatments and suggests where future progress may occur
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Published date: 2006
Keywords:
colorectal cancer, first-line, 5-fluorouracil, irinotecan, oxaliplatin, targeted agents
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Local EPrints ID: 62916
URI: http://eprints.soton.ac.uk/id/eprint/62916
ISSN: 0007-0920
PURE UUID: abe5b6d3-1e9d-424d-b4a1-c2284e3bd00f
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Date deposited: 04 Sep 2008
Last modified: 16 Mar 2024 02:58
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Author:
M. Saunders
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