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Late toxicity is not increased in BRCA1/BRCA2 mutation carriers undergoing breast radiotherapy in the United Kingdom

Late toxicity is not increased in BRCA1/BRCA2 mutation carriers undergoing breast radiotherapy in the United Kingdom
Late toxicity is not increased in BRCA1/BRCA2 mutation carriers undergoing breast radiotherapy in the United Kingdom
Purpose: To undertake the first substantial clinical study of breast radiotherapy toxicity in BRCA1 and BRCA2 mutation carriers in the United Kingdom. Experimental Design: Acute and late radiation effects were evaluated in a retrospective study of 55 BRCA1 and BRCA2 mutation carriers treated with radiotherapy for breast cancer at four centers between 1983 and 2002. Individual matching with controls who had sporadic breast cancer was undertaken for age at diagnosis, time since completion of radiation, and treatment variables. Detailed assessments were undertaken by one examiner. Median follow-up was 6.75 years for carriers and 7.75 years for controls. Rates of late events (rib fractures, lung fibrosis, necrosis of soft tissue/bone, and pericarditis) as well as LENT-SOMA scores and clinical photography scores of breast size, shape, and skin telangiectasia were the primary end points. Results: No increase in clinically significant late toxicity was seen in the mutation carriers. Conclusions: These data add substantial weight to the evidence that the outcomes in the treated breast from radiotherapy in women with BRCA1 or BRCA2 mutations are comparable with those in women with sporadic breast cancer
radiotherapy, breast cancer, brca2, breast-cancer, mutations, brca1, family-history, breast, radiation-therapy, women, outcomes, mutation, brca2 mutations, cancer, conserving therapy
1078-0432
7025-7032
Shanley, Susan
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McReynolds, Kate
e1d58175-f4e8-42b8-9f46-d4adaddd0e39
Rdern-Jones, Audrey
bf4f791b-5d83-4fed-80ca-9f35b42eeda4
Ahern, Roger
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Fernando, Indrajit
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Yarnold, John
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Evans, Gareth
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Eccles, Diana
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Hodgson, Shirley
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Ashley, Sue
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Ashcroft, Linda
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Tutt, Andrew
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Bancroft, Elizabeth
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Short, Susan
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Gui, Gerald
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Barr, Lester
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Baildam, Andrew
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Howell, Anthony
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Royle, Gavin
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Pierce, Lori
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Easton, Douglas
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Eeles, Rosalind
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The Breast Unit of the Royal Marsden NHS Foundation Trust
Shanley, Susan
a0d8bf7d-730c-40ad-b9d0-d6e85f87fb95
McReynolds, Kate
e1d58175-f4e8-42b8-9f46-d4adaddd0e39
Rdern-Jones, Audrey
bf4f791b-5d83-4fed-80ca-9f35b42eeda4
Ahern, Roger
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Fernando, Indrajit
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Yarnold, John
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Evans, Gareth
ee001bc1-9b29-4a58-a251-a27b18eff669
Eccles, Diana
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Hodgson, Shirley
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Ashley, Sue
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Ashcroft, Linda
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Tutt, Andrew
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Bancroft, Elizabeth
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Short, Susan
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Gui, Gerald
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Barr, Lester
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Baildam, Andrew
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Howell, Anthony
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Royle, Gavin
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Pierce, Lori
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Easton, Douglas
de2d61a0-74d3-4548-9cd8-36ea7642ff29
Eeles, Rosalind
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Shanley, Susan, McReynolds, Kate, Rdern-Jones, Audrey, Ahern, Roger, Fernando, Indrajit, Yarnold, John, Evans, Gareth, Eccles, Diana, Hodgson, Shirley, Ashley, Sue, Ashcroft, Linda, Tutt, Andrew, Bancroft, Elizabeth, Short, Susan, Gui, Gerald, Barr, Lester, Baildam, Andrew, Howell, Anthony, Royle, Gavin, Pierce, Lori, Easton, Douglas and Eeles, Rosalind , The Breast Unit of the Royal Marsden NHS Foundation Trust (2006) Late toxicity is not increased in BRCA1/BRCA2 mutation carriers undergoing breast radiotherapy in the United Kingdom. Clinical Cancer Research, 12 (23), 7025-7032.

Record type: Article

Abstract

Purpose: To undertake the first substantial clinical study of breast radiotherapy toxicity in BRCA1 and BRCA2 mutation carriers in the United Kingdom. Experimental Design: Acute and late radiation effects were evaluated in a retrospective study of 55 BRCA1 and BRCA2 mutation carriers treated with radiotherapy for breast cancer at four centers between 1983 and 2002. Individual matching with controls who had sporadic breast cancer was undertaken for age at diagnosis, time since completion of radiation, and treatment variables. Detailed assessments were undertaken by one examiner. Median follow-up was 6.75 years for carriers and 7.75 years for controls. Rates of late events (rib fractures, lung fibrosis, necrosis of soft tissue/bone, and pericarditis) as well as LENT-SOMA scores and clinical photography scores of breast size, shape, and skin telangiectasia were the primary end points. Results: No increase in clinically significant late toxicity was seen in the mutation carriers. Conclusions: These data add substantial weight to the evidence that the outcomes in the treated breast from radiotherapy in women with BRCA1 or BRCA2 mutations are comparable with those in women with sporadic breast cancer

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More information

Published date: 1 December 2006
Keywords: radiotherapy, breast cancer, brca2, breast-cancer, mutations, brca1, family-history, breast, radiation-therapy, women, outcomes, mutation, brca2 mutations, cancer, conserving therapy

Identifiers

Local EPrints ID: 62924
URI: http://eprints.soton.ac.uk/id/eprint/62924
ISSN: 1078-0432
PURE UUID: c2467f32-8ee6-48dd-b9a7-3f4d43de6398

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Date deposited: 04 Sep 2008
Last modified: 13 Mar 2019 20:26

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Contributors

Author: Susan Shanley
Author: Kate McReynolds
Author: Audrey Rdern-Jones
Author: Roger Ahern
Author: Indrajit Fernando
Author: John Yarnold
Author: Gareth Evans
Author: Diana Eccles
Author: Shirley Hodgson
Author: Sue Ashley
Author: Linda Ashcroft
Author: Andrew Tutt
Author: Elizabeth Bancroft
Author: Susan Short
Author: Gerald Gui
Author: Lester Barr
Author: Andrew Baildam
Author: Anthony Howell
Author: Gavin Royle
Author: Lori Pierce
Author: Douglas Easton
Author: Rosalind Eeles

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