Requirement for CD70 in CD4(+) Th cell-dependent and innate receptor-mediated CD8(+) T cell priming
Requirement for CD70 in CD4(+) Th cell-dependent and innate receptor-mediated CD8(+) T cell priming
Dendritic cell (DC) conditioning by CD4(+) T cells, or via engagement of innate receptors, is thought to be essential for CD8(+) T cell priming. However, the molecular features that distinguish a conditioned DC from an unconditioned DC are poorly defined. In this study. we investigate the role of CD70, a member of the TNF superfamily that is expressed on activated DC, in CD4+ Th-dependent and -independent CD8(+) T cell responses. We demonstrate that CD70 is required for CD4(+) T cell-dependent priming of CD8(+) T cells as well as priming mediated by the viral signature, dsRNA. Accordingly, mice that were subjected to CD70 blockade during the primary response fail to generate a memory CD8(+) T cell response. Furthermore, we find that CD70 is dispensable for CD4(+) T cell expansion and help for B cells, thus suggesting a direct role for CD70 in CD8(+) T cell priming. Our results show that the innate and adaptive (CD4(+) T cells) arms of the immune system use a common signaling pathway in driving CD8(+) T cell responses and suggest that expression of CD70 on DC represents the hallmark of conditioned DC.
cd70, dendritic cells, expression, toll-like receptor-3, double-stranded-rna, responses in-vivo, viral-infection, responses, cd4-t-cell help, clonal expansion, antigen-presenting cells, cd8-t-cell memory, t-cells, cutting edge, innate
2969-2975
Taraban, Vadim Y.
d709dcbb-ff36-4514-85da-08ca68aafcd3
Rowley, Tania F.
3a29866f-3e2c-4ee8-8fe6-fd189ac1eb3d
Tough, David F.
d1f1b88c-eaaf-45d6-ab2e-1bf74c52b41f
Al-Shamkhani, Aymen
0a40b3ce-9d71-4d41-9369-7212f0a84504
2006
Taraban, Vadim Y.
d709dcbb-ff36-4514-85da-08ca68aafcd3
Rowley, Tania F.
3a29866f-3e2c-4ee8-8fe6-fd189ac1eb3d
Tough, David F.
d1f1b88c-eaaf-45d6-ab2e-1bf74c52b41f
Al-Shamkhani, Aymen
0a40b3ce-9d71-4d41-9369-7212f0a84504
Taraban, Vadim Y., Rowley, Tania F., Tough, David F. and Al-Shamkhani, Aymen
(2006)
Requirement for CD70 in CD4(+) Th cell-dependent and innate receptor-mediated CD8(+) T cell priming.
Journal of Immunology, 177 (5), .
Abstract
Dendritic cell (DC) conditioning by CD4(+) T cells, or via engagement of innate receptors, is thought to be essential for CD8(+) T cell priming. However, the molecular features that distinguish a conditioned DC from an unconditioned DC are poorly defined. In this study. we investigate the role of CD70, a member of the TNF superfamily that is expressed on activated DC, in CD4+ Th-dependent and -independent CD8(+) T cell responses. We demonstrate that CD70 is required for CD4(+) T cell-dependent priming of CD8(+) T cells as well as priming mediated by the viral signature, dsRNA. Accordingly, mice that were subjected to CD70 blockade during the primary response fail to generate a memory CD8(+) T cell response. Furthermore, we find that CD70 is dispensable for CD4(+) T cell expansion and help for B cells, thus suggesting a direct role for CD70 in CD8(+) T cell priming. Our results show that the innate and adaptive (CD4(+) T cells) arms of the immune system use a common signaling pathway in driving CD8(+) T cell responses and suggest that expression of CD70 on DC represents the hallmark of conditioned DC.
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Published date: 2006
Keywords:
cd70, dendritic cells, expression, toll-like receptor-3, double-stranded-rna, responses in-vivo, viral-infection, responses, cd4-t-cell help, clonal expansion, antigen-presenting cells, cd8-t-cell memory, t-cells, cutting edge, innate
Identifiers
Local EPrints ID: 62945
URI: http://eprints.soton.ac.uk/id/eprint/62945
ISSN: 0022-1767
PURE UUID: e31fd023-1da7-4b76-a2f2-abe6924663a9
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Date deposited: 05 Sep 2008
Last modified: 08 Jan 2022 02:48
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Contributors
Author:
Vadim Y. Taraban
Author:
Tania F. Rowley
Author:
David F. Tough
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