Breast cancer is a promising target for vaccination using cancer-testis antigens known to elicit immune responses


Taylor, Mark, Bolton, Louise M., Johnson, Peter, Elliott, Tim and Murray, Nick (2007) Breast cancer is a promising target for vaccination using cancer-testis antigens known to elicit immune responses Breast Cancer Research, 9, (4, R46), 7pp. (doi:10.1186/bcr1749). (PMID:17650306).

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Description/Abstract

Introduction Cancer-testis antigens ( CTAGs) are expressed solely in germ cells and in malignant tissues. They are targets of immune responses mediated by cytotoxic T cells in some cancers, and there is much interest in developing vaccines that induce these responses. The purpose of the present study was to ascertain the frequency of expression of CTAGs in breast cancer. Methods Breast tumours were collected sequentially in the Southampton Tumour Bank from donors who had given written informed consent. Stored samples where there was sufficient material were sampled in sequence. An initial series of 42 tumours was screened for expression of 17 different CTAGs. A second panel of 40 tumours was screened for the expression of those antigens present in the first panel. Results Ninety-three per cent of tumours in the first series expressed at least one CTAG, and 62% expressed the single antigen CTAG1. Eighty per cent of tumours in the second series expressed at least one CTAG, 50% expressing CTAG1. Tumours exhibiting higher risk features tended to express more CTAGs. Conclusion More than two- thirds of breast cancers would be covered by a vaccine directed against just three CTAGs CTAG1, BAGE1, and MAGEA10- all of which are known to be targets of cytotoxic-T-lymphocyte responses.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1186/bcr1749
ISSNs: 1465-5411 (print)
Related URLs:
Keywords: breast cancer, breast, antigen, tissue, risk, gene, responses, t cells, expression, time, cells, breast-cancer, human-melanoma, tumors, cancer, tumours, vaccine, cytolytic t-lymphocytes, features, immune-responses, cell, ny-eso-1, t-cells
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
ePrint ID: 62951
Date :
Date Event
24 July 2007Published
Date Deposited: 03 Oct 2008
Last Modified: 18 Feb 2017 01:15
Projects:
UNSPECIFIED
Funded by: CRUK (UNSPECIFIED)
UNSPECIFIED to UNSPECIFIED
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/62951

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