The University of Southampton
University of Southampton Institutional Repository

Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: a pooled analysis of three clinical trials

Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: a pooled analysis of three clinical trials
Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: a pooled analysis of three clinical trials
The aim of this study was to determine the benefits of chemotherapy for oesophago-gastric cancer (OGC) in patients 70 years and above ( >= 70) in comparison to younger patients. 1080 patients were enrolled into three randomised controlled trials assessing fluorouracil-based combination chemotherapy. Patients received either a platinum-containing regimen (ECF, MCF), PVI 5-FU (protracted venous infusion of 5-fluorouracil) +/- mitomycin C (MMC), or FAMTX. Of the 1080 patients randomised, 257 (23.8%) were aged >= 70 years. There were no significant differences in the incidence of grades 3/4 toxicity between the two cohorts. Objective and symptomatic response rates, failure-free and overall survival were not significantly different. In a multivariate analysis, independent prognostic factors for survival were performance status and locally advanced disease, not age. Patients >= 70 years with OGC obtained similar benefits from palliative chemotherapy with respect to symptomatic response, tumour regression and survival, without increased toxicities. (c) 2006 Elsevier Ltd. All rights reserved
oesphago-gastric, chemotherapy, elderly
0959-8049
827-834
Trumper, M.
0f29f44c-4a0b-456d-b030-d8b7a666884a
Ross, P.J.
16ec2053-0b42-440b-9f45-3991036a2c13
Cunningham, D.
02b4fd3a-f452-4419-96a7-f98f609f098d
Norman, A.R.
9d5636c7-72da-4a29-80f1-e3d79c501639
Hawkins, R.
359a61bf-7393-4b1d-a1c1-cecc85ee8107
Seymour, M.
79cb91bf-b3e6-4222-82cf-c0072be29613
Harper, P.
93a9f992-d1de-4748-b77a-00917cf3e879
Iveson, T.
867cb6c5-ea9a-4521-a4cc-4cd4d2503b3a
Nicolson, M.
293bfbb1-f76e-408e-a6e3-615dffb59acd
Hickish, T.
d17bf903-3f13-4b46-9389-f0f458083442
Trumper, M.
0f29f44c-4a0b-456d-b030-d8b7a666884a
Ross, P.J.
16ec2053-0b42-440b-9f45-3991036a2c13
Cunningham, D.
02b4fd3a-f452-4419-96a7-f98f609f098d
Norman, A.R.
9d5636c7-72da-4a29-80f1-e3d79c501639
Hawkins, R.
359a61bf-7393-4b1d-a1c1-cecc85ee8107
Seymour, M.
79cb91bf-b3e6-4222-82cf-c0072be29613
Harper, P.
93a9f992-d1de-4748-b77a-00917cf3e879
Iveson, T.
867cb6c5-ea9a-4521-a4cc-4cd4d2503b3a
Nicolson, M.
293bfbb1-f76e-408e-a6e3-615dffb59acd
Hickish, T.
d17bf903-3f13-4b46-9389-f0f458083442

Trumper, M., Ross, P.J., Cunningham, D., Norman, A.R., Hawkins, R., Seymour, M., Harper, P., Iveson, T., Nicolson, M. and Hickish, T. (2006) Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: a pooled analysis of three clinical trials. European Journal of Cancer, 42 (7), 827-834. (doi:10.1016/j.ejca.2005.08.044).

Record type: Article

Abstract

The aim of this study was to determine the benefits of chemotherapy for oesophago-gastric cancer (OGC) in patients 70 years and above ( >= 70) in comparison to younger patients. 1080 patients were enrolled into three randomised controlled trials assessing fluorouracil-based combination chemotherapy. Patients received either a platinum-containing regimen (ECF, MCF), PVI 5-FU (protracted venous infusion of 5-fluorouracil) +/- mitomycin C (MMC), or FAMTX. Of the 1080 patients randomised, 257 (23.8%) were aged >= 70 years. There were no significant differences in the incidence of grades 3/4 toxicity between the two cohorts. Objective and symptomatic response rates, failure-free and overall survival were not significantly different. In a multivariate analysis, independent prognostic factors for survival were performance status and locally advanced disease, not age. Patients >= 70 years with OGC obtained similar benefits from palliative chemotherapy with respect to symptomatic response, tumour regression and survival, without increased toxicities. (c) 2006 Elsevier Ltd. All rights reserved

Full text not available from this repository.

More information

Published date: May 2006
Keywords: oesphago-gastric, chemotherapy, elderly

Identifiers

Local EPrints ID: 62961
URI: http://eprints.soton.ac.uk/id/eprint/62961
ISSN: 0959-8049
PURE UUID: 68ba835e-065f-4023-bf54-a46bc31c5e93

Catalogue record

Date deposited: 04 Sep 2008
Last modified: 13 Mar 2019 20:26

Export record

Altmetrics

Contributors

Author: M. Trumper
Author: P.J. Ross
Author: D. Cunningham
Author: A.R. Norman
Author: R. Hawkins
Author: M. Seymour
Author: P. Harper
Author: T. Iveson
Author: M. Nicolson
Author: T. Hickish

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×