Recombinant factor VIIa in the management of pulmonary hemorrhage associated with metastatic choriocarcinoma
Recombinant factor VIIa in the management of pulmonary hemorrhage associated with metastatic choriocarcinoma
A 25-year-old man presented in September 2005 with relapsed
metastatic germ cell tumor and a rapidly rising serum human beta chorionic gonadotropin (HCG; from 10,000 to 40,000 U/L over the preceding 10 days). He had been diagnosed 18 months earlier with International Germ Cell Cancer Collaborative Group (IGCCCG) poor prognosis extragonadal retroperitoneal metastatic germ cell cancer. He had presented then with lower back pain, hemoptysis, and weight loss. A computed tomography (CT) scan of the brain, chest, abdomen,andpelvis hadshowna large retroperitoneal mass with a left hydronephrosis, multiple pulmonary deposits, and multiple brain metastases. Blood markers showed HCG 522,442 U/L, alphafetoprotein 5 KU/L, and lactate dehydrogenase 1,500 U/L. Testicular examination and ultrasound were unremarkable.
activated factor-vii, management, germ-cell tumors, mechanism, time, chemotherapy, cisplatin
1008-1010
Wheater, M.J.
3691c3d8-8589-4693-a0dc-c6a8648cd7df
Mead, G.M.
8a97f978-9c66-4a16-bb03-dd83d20b06a0
Bhandari, S.
5d3426ee-1916-4370-9552-7b389762d1af
Fennell, J.
b5732611-ba5b-42c8-8b5d-bc868966f1f7
2008
Wheater, M.J.
3691c3d8-8589-4693-a0dc-c6a8648cd7df
Mead, G.M.
8a97f978-9c66-4a16-bb03-dd83d20b06a0
Bhandari, S.
5d3426ee-1916-4370-9552-7b389762d1af
Fennell, J.
b5732611-ba5b-42c8-8b5d-bc868966f1f7
Wheater, M.J., Mead, G.M., Bhandari, S. and Fennell, J.
(2008)
Recombinant factor VIIa in the management of pulmonary hemorrhage associated with metastatic choriocarcinoma.
Journal of Clinical Oncology, 26 (6), .
(doi:10.1200/JCO.2007.14.8486).
Abstract
A 25-year-old man presented in September 2005 with relapsed
metastatic germ cell tumor and a rapidly rising serum human beta chorionic gonadotropin (HCG; from 10,000 to 40,000 U/L over the preceding 10 days). He had been diagnosed 18 months earlier with International Germ Cell Cancer Collaborative Group (IGCCCG) poor prognosis extragonadal retroperitoneal metastatic germ cell cancer. He had presented then with lower back pain, hemoptysis, and weight loss. A computed tomography (CT) scan of the brain, chest, abdomen,andpelvis hadshowna large retroperitoneal mass with a left hydronephrosis, multiple pulmonary deposits, and multiple brain metastases. Blood markers showed HCG 522,442 U/L, alphafetoprotein 5 KU/L, and lactate dehydrogenase 1,500 U/L. Testicular examination and ultrasound were unremarkable.
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Published date: 2008
Keywords:
activated factor-vii, management, germ-cell tumors, mechanism, time, chemotherapy, cisplatin
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Local EPrints ID: 62968
URI: http://eprints.soton.ac.uk/id/eprint/62968
ISSN: 1527-7755
PURE UUID: 372c0373-10f5-4dc3-bc79-e9e545b163d3
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Date deposited: 05 Sep 2008
Last modified: 15 Mar 2024 11:33
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Contributors
Author:
M.J. Wheater
Author:
G.M. Mead
Author:
S. Bhandari
Author:
J. Fennell
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