The effect of mannitol on renal function following cardio-pulmonary bypass in patients with normal pre-operative creatinine
The effect of mannitol on renal function following cardio-pulmonary bypass in patients with normal pre-operative creatinine
Mannitol is often added to the cardiopulmonary bypass pump prime to reduce the incidence of renal dysfunction, but studies so far have been inconclusive. Urinary excretion of microalbumin and retinol binding protein are more sensitive than routine biochemical tests of renal function after cardiac surgery. We performed a double-blind, randomised, controlled trial in cardiac surgical patients with pre-operative plasma creatinine < 130 mu mol.l(-1). Twenty patients received 0.5 g.kg(-1) of mannitol in the pump prime, whereas 20 control patients received an equivalent volume of Hartmann's solution. Blood and urine samples were taken on the day before surgery and daily for 5 days postoperatively for measurement of plasma urea and creatinine, urinary creatinine, retinol binding protein and microalbumin. We found no differences between the mannitol and control patients for any measured variable, and conclude that mannitol has little impact on renal function in patients with normal pre-operative plasma creatinine concentrations
failure, trial, binding, surgical-patients, cardiac-surgery, revascularization, open-heart surgery, time, risk-factors, retinol-binding-protein, sample, impact, prevention, temperature, patient, protein, double-blind, dysfunction, surgery, binding-protein
576-582
Yallop, K.G.
4990ba45-bdbe-471f-a1a3-0a3e3ed27ebe
Sheppard, S.V.
e1cda445-ccea-4633-a11a-95a28ca31313
Smith, D.C.
217b19f1-7588-4d54-a062-8394eea6dea1
2008
Yallop, K.G.
4990ba45-bdbe-471f-a1a3-0a3e3ed27ebe
Sheppard, S.V.
e1cda445-ccea-4633-a11a-95a28ca31313
Smith, D.C.
217b19f1-7588-4d54-a062-8394eea6dea1
Yallop, K.G., Sheppard, S.V. and Smith, D.C.
(2008)
The effect of mannitol on renal function following cardio-pulmonary bypass in patients with normal pre-operative creatinine.
Anaesthesia, 63 (6), .
(doi:10.1111/j.1365-2044.2008.05540.x).
Abstract
Mannitol is often added to the cardiopulmonary bypass pump prime to reduce the incidence of renal dysfunction, but studies so far have been inconclusive. Urinary excretion of microalbumin and retinol binding protein are more sensitive than routine biochemical tests of renal function after cardiac surgery. We performed a double-blind, randomised, controlled trial in cardiac surgical patients with pre-operative plasma creatinine < 130 mu mol.l(-1). Twenty patients received 0.5 g.kg(-1) of mannitol in the pump prime, whereas 20 control patients received an equivalent volume of Hartmann's solution. Blood and urine samples were taken on the day before surgery and daily for 5 days postoperatively for measurement of plasma urea and creatinine, urinary creatinine, retinol binding protein and microalbumin. We found no differences between the mannitol and control patients for any measured variable, and conclude that mannitol has little impact on renal function in patients with normal pre-operative plasma creatinine concentrations
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Published date: 2008
Keywords:
failure, trial, binding, surgical-patients, cardiac-surgery, revascularization, open-heart surgery, time, risk-factors, retinol-binding-protein, sample, impact, prevention, temperature, patient, protein, double-blind, dysfunction, surgery, binding-protein
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Local EPrints ID: 62975
URI: http://eprints.soton.ac.uk/id/eprint/62975
ISSN: 0003-2409
PURE UUID: c869a8c1-e79b-434e-a24b-a926bb4ee832
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Date deposited: 02 Sep 2008
Last modified: 15 Mar 2024 11:33
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Author:
K.G. Yallop
Author:
S.V. Sheppard
Author:
D.C. Smith
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