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An integrated multimodal acoustic particle manipulator and optical evanescent field waveguide

Glynne-Jones, Peter, Hill, Martyn, Townsend, Rosemary J., Harris, Nicholas R., Wilkinson, James S., Zhang, Fan and Melvin, Tracy (2008) An integrated multimodal acoustic particle manipulator and optical evanescent field waveguide Journal of the Acoustical Society of America, 123, (5), p.3925. (doi:10.1121/1.2935963).

Record type: Article

Abstract

A new acoustic-optical-microfluidic system is presented for the manipulation of bead-tagged DNA molecules. Acoustic radiation forces are used to manipulate microspheres into and away from the evanescent field of a laser coupled waveguide that is integrated into the reflector of the acoustic chamber. With suitable fluorophores the presence of the target DNA can be detected with a fluorescence microscope enabling large populations of beads to be examined simultaneously. The integrated waveguide and multimodal acoustic chamber are presented here, with results showing that the microspheres can be successfully detected as they are brought into the evanescent field using a quarter-wave acoustic configuration. It is also shown that by measuring the time of flight of a microsphere between the half- and quarterwave nodal planes the bead size can be determined, providing a means of multiplexing the detection (detecting a range of different target DNA sequences).

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More information

Published date: May 2008
Additional Information: (Paper 5pPAa2 at Acoustics '08, 4 July, Paris )

Identifiers

Local EPrints ID: 63332
URI: http://eprints.soton.ac.uk/id/eprint/63332
ISSN: 0001-4966
PURE UUID: 2c4f8b75-19d9-4450-a461-b4495d23895d
ORCID for Peter Glynne-Jones: ORCID iD orcid.org/0000-0001-5684-3953
ORCID for Martyn Hill: ORCID iD orcid.org/0000-0001-6448-9448
ORCID for Nicholas R. Harris: ORCID iD orcid.org/0000-0003-4122-2219
ORCID for James S. Wilkinson: ORCID iD orcid.org/0000-0003-4712-1697

Catalogue record

Date deposited: 08 Oct 2008
Last modified: 17 Jul 2017 14:17

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