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Autism symptoms in attention-deficit/hyperactivity disorder: a familial trait which correlates with conduct, oppositional defiant, language and motor disorders

Mulligan, Aisling, Anney, Richard J.L., O'Regan, Myra, Chen, Wai, Butler, Louise, Fitzgerald, Michael, Buitelaar, Jan, Steinhausen, Hans-Christoph, Rothenberger, Aribert, Minderaa, Ruud, Nijmeijer, Judith, Hoekstra, Peter J., Oades, Robert D., Roeyers, Herbert, Buschgens, Cathelijne, Christiansen, Hanna, Franke, Barbara, Gabriels, Isabel, Hartman, Catharina, Kuntsi, Jonna, Marco, Rafaela, Meidad, Sheera, Mueller, Ueli, Psychogiou, Lamprini, Rommelse, Nanda, Thompson, Margaret, Uebel, Henrik, Banaschewski, Tobias, Ebstein, Richard, Eisenberg, Jacques, Manor, Iris, Miranda, Ana, Mulas, Fernando, Sergeant, Joseph, Sonuga-Barke, Edmund, Asherson, Phil, Faraone, Stephen V. and Gill, Michael (2009) Autism symptoms in attention-deficit/hyperactivity disorder: a familial trait which correlates with conduct, oppositional defiant, language and motor disorders Journal of Autism and Developmental Disorders, 39, pp. 197-209. (doi:10.1007/s10803-008-0621-3).

Record type: Article


It is hypothesised that autism symptoms are present in Attention-Deficit/Hyperactivity Disorder (ADHD), are familial and index subtypes of ADHD. Autism symptoms were compared in 821 ADHD probands, 1050 siblings and 149 controls. Shared familiality of autism symptoms and ADHD was calculated using DeFries-Fulker analysis. Autism symptoms were higher in probands than siblings or controls, and higher in male siblings than male controls. Autism symptoms were familial, partly shared with familiality of ADHD in males. Latent class analysis using SCQ-score yielded five classes; Class 1(31%) had few autism symptoms and low comorbidity; Classes 2–4 were intermediate; Class 5(7%) had high autism symptoms and comorbidity. Thus autism symptoms in ADHD represent a familial trait associated with increased neurodevelopmental and oppositional/conduct disorders.

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Published date: 2009
Keywords: adhd, autism, familiality, oppositional disorders, motor disorder, language disorder


Local EPrints ID: 63807
ISSN: 0162-3257
PURE UUID: ae2b2eec-52b8-4e67-b01c-37b31f543b16

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Date deposited: 05 Nov 2008
Last modified: 17 Jul 2017 14:15

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Author: Aisling Mulligan
Author: Richard J.L. Anney
Author: Myra O'Regan
Author: Wai Chen
Author: Louise Butler
Author: Michael Fitzgerald
Author: Jan Buitelaar
Author: Hans-Christoph Steinhausen
Author: Aribert Rothenberger
Author: Ruud Minderaa
Author: Judith Nijmeijer
Author: Peter J. Hoekstra
Author: Robert D. Oades
Author: Herbert Roeyers
Author: Cathelijne Buschgens
Author: Hanna Christiansen
Author: Barbara Franke
Author: Isabel Gabriels
Author: Catharina Hartman
Author: Jonna Kuntsi
Author: Rafaela Marco
Author: Sheera Meidad
Author: Ueli Mueller
Author: Lamprini Psychogiou
Author: Nanda Rommelse
Author: Margaret Thompson
Author: Henrik Uebel
Author: Tobias Banaschewski
Author: Richard Ebstein
Author: Jacques Eisenberg
Author: Iris Manor
Author: Ana Miranda
Author: Fernando Mulas
Author: Joseph Sergeant
Author: Edmund Sonuga-Barke
Author: Phil Asherson
Author: Stephen V. Faraone
Author: Michael Gill

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