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Conduct disorder and ADHD: evaluation of conduct problems as a categorial and quantitative trait in the international multicentre ADHD genetics study (In special issue: Special Issue on the Genetics of ADHD Dedicated to the Memory of Richard Todd)

Conduct disorder and ADHD: evaluation of conduct problems as a categorial and quantitative trait in the international multicentre ADHD genetics study (In special issue: Special Issue on the Genetics of ADHD Dedicated to the Memory of Richard Todd)
Conduct disorder and ADHD: evaluation of conduct problems as a categorial and quantitative trait in the international multicentre ADHD genetics study (In special issue: Special Issue on the Genetics of ADHD Dedicated to the Memory of Richard Todd)
Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by inattention, excessive motor activity, impulsivity, and distractibility. Individuals with ADHD have significant impairment in family and peer relations, academic functioning, and show high co-morbidity with a wide range of psychiatric disorders including oppositional defiant disorder (ODD), conduct disorder (CD), anxiety disorder, depression, substance abuse, and pervasive developmental disorder (PDD). Family studies suggest that ADHD + CD represents a specific subtype of the ADHD disorder with familial risk factors only partly overlapping with those of ADHD alone. We performed a hypothesis-free analysis of the GAIN-ADHD sample to identify markers and genes important in the development of conduct problems in a European cohort of individuals with ADHD. Using the Family-Based Association Test (FBAT) package we examined three measures of conduct problems in 1,043,963 autosomal markers. This study is part of a series of exploratory analyses to identify candidate genes that may be important in ADHD and ADHD-related traits, such as conduct problems. We did not find genome-wide statistical significance (P < 5 × 10-7) for any of the tested markers and the three conduct problem traits. Fifty-four markers reached strong GWA signals (P < 10-5). We discuss these findings in the context of putative candidate genes and the implications of these findings in the understanding of the etiology of ADHD + CD. We aimed to achieve insight into the genetic etiology of a trait using a hypothesis-free study design and were able to identify a number of biologically interesting markers and genes for follow-up studies.
1552-4841
1369-1378
Anney, Richard J.L.
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Lasky-Su, Jessica
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Ó'Dúshláine, Colm
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Kenny, Elaine
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Neale, Benjamin M.
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Mulligan, Aisling
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Franke, Barbara
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Zhou, Kaixin
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Chen, Wai
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Christiansen, Hanna
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Arias-Vasquez, Alejandro
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Banaschewski, Tobias
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Buitelaar, Jan
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Ebstein, Richard
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Miranda, Ana
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Mulas, Fernando
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Oades, Robert D.
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Roeyers, Herbert
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Rothenberger, Aribert
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Sergeant, Joseph
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Sonuga-Barke, Edmund
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Steinhausen, Hans
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Asherson, Philip
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Faraone, Stephen V.
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Gill, Michael
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Anney, Richard J.L.
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Lasky-Su, Jessica
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Ó'Dúshláine, Colm
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Kenny, Elaine
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Neale, Benjamin M.
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Mulligan, Aisling
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Franke, Barbara
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Zhou, Kaixin
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Chen, Wai
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Christiansen, Hanna
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Arias-Vasquez, Alejandro
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Banaschewski, Tobias
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Buitelaar, Jan
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Ebstein, Richard
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Miranda, Ana
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Mulas, Fernando
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Oades, Robert D.
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Roeyers, Herbert
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Rothenberger, Aribert
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Sergeant, Joseph
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Sonuga-Barke, Edmund
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Steinhausen, Hans
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Asherson, Philip
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Faraone, Stephen V.
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Gill, Michael
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Anney, Richard J.L., Lasky-Su, Jessica, Ó'Dúshláine, Colm, Kenny, Elaine, Neale, Benjamin M., Mulligan, Aisling, Franke, Barbara, Zhou, Kaixin, Chen, Wai, Christiansen, Hanna, Arias-Vasquez, Alejandro, Banaschewski, Tobias, Buitelaar, Jan, Ebstein, Richard, Miranda, Ana, Mulas, Fernando, Oades, Robert D., Roeyers, Herbert, Rothenberger, Aribert, Sergeant, Joseph, Sonuga-Barke, Edmund, Steinhausen, Hans, Asherson, Philip, Faraone, Stephen V. and Gill, Michael (2008) Conduct disorder and ADHD: evaluation of conduct problems as a categorial and quantitative trait in the international multicentre ADHD genetics study (In special issue: Special Issue on the Genetics of ADHD Dedicated to the Memory of Richard Todd). American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147B (8), 1369-1378. (doi:10.1002/ajmg.b.30871).

Record type: Article

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by inattention, excessive motor activity, impulsivity, and distractibility. Individuals with ADHD have significant impairment in family and peer relations, academic functioning, and show high co-morbidity with a wide range of psychiatric disorders including oppositional defiant disorder (ODD), conduct disorder (CD), anxiety disorder, depression, substance abuse, and pervasive developmental disorder (PDD). Family studies suggest that ADHD + CD represents a specific subtype of the ADHD disorder with familial risk factors only partly overlapping with those of ADHD alone. We performed a hypothesis-free analysis of the GAIN-ADHD sample to identify markers and genes important in the development of conduct problems in a European cohort of individuals with ADHD. Using the Family-Based Association Test (FBAT) package we examined three measures of conduct problems in 1,043,963 autosomal markers. This study is part of a series of exploratory analyses to identify candidate genes that may be important in ADHD and ADHD-related traits, such as conduct problems. We did not find genome-wide statistical significance (P < 5 × 10-7) for any of the tested markers and the three conduct problem traits. Fifty-four markers reached strong GWA signals (P < 10-5). We discuss these findings in the context of putative candidate genes and the implications of these findings in the understanding of the etiology of ADHD + CD. We aimed to achieve insight into the genetic etiology of a trait using a hypothesis-free study design and were able to identify a number of biologically interesting markers and genes for follow-up studies.

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Published date: 5 December 2008

Identifiers

Local EPrints ID: 64138
URI: https://eprints.soton.ac.uk/id/eprint/64138
ISSN: 1552-4841
PURE UUID: 4c795d63-956d-4ffc-9a29-c52092262cfd

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Date deposited: 04 Dec 2008
Last modified: 13 Mar 2019 20:22

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Contributors

Author: Richard J.L. Anney
Author: Jessica Lasky-Su
Author: Colm Ó'Dúshláine
Author: Elaine Kenny
Author: Benjamin M. Neale
Author: Aisling Mulligan
Author: Barbara Franke
Author: Kaixin Zhou
Author: Wai Chen
Author: Hanna Christiansen
Author: Alejandro Arias-Vasquez
Author: Tobias Banaschewski
Author: Jan Buitelaar
Author: Richard Ebstein
Author: Ana Miranda
Author: Fernando Mulas
Author: Robert D. Oades
Author: Herbert Roeyers
Author: Aribert Rothenberger
Author: Joseph Sergeant
Author: Edmund Sonuga-Barke
Author: Hans Steinhausen
Author: Philip Asherson
Author: Stephen V. Faraone
Author: Michael Gill

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