Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder (In Special Issue on the Genetics of ADHD Dedicated to the Memory of Richard Todd)

Zhou, Kaixin, Dempfle, Astrid, Arcos-Burgos, Mauricio, Bakker, Steven C., Banaschewski, Tobias, Biederman, Joseph, Buitelaar, Jan, Castellanos, F. Xavier, Doyle, Alysa, Ebstein, Richard P., Ekholm, Jenny, Forabosco, Paola, Franke, Barbara, Freitag, Christine, Friedel, Susann, Gill, Michael, Hebebrand, Johannes, Hinney, Anke, Jacob, Christian, Lesch, Klaus Peter, Loo, Sandra K., Lopera, Francisco, McCracken, James T., McGough, James J., Meyer, Jobst, Mick, Eric, Miranda, Ana, Muenkel, Maximilian, Mulas, Fernando, Nelson, Stanley F., Nguyen, T.Trang, Oades, Robert D., Ogdie, Matthew N., Palacio, Juan David, Pineda, David, Reif, Andreas, Renner, Tobias J., Roeyers, Herbert, Romanos, Marcel, Rothenberger, Aribert, Schäfer, Helmut, Sergeant, Joseph, Sinke, Richard J., Smalley, Susan L., Sonuga-Barke, Edmund, Steinhausen, Hans-Christoph, van der Meueln, Emma, Walitza, Susanne, Warnke, Andreas, Lewis, Cathryn M., Faraone, Stephen V. and Asherson, Philip (2008) Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder (In Special Issue on the Genetics of ADHD Dedicated to the Memory of Richard Todd). American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 147B (8), 1392-1398. (doi:10.1002/ajmg.b.30878).

Abstract

Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (PSR = 0.00034, POR = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes.

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