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Default-mode brain dysfunction in mental disorders: a systematic review

Default-mode brain dysfunction in mental disorders: a systematic review
Default-mode brain dysfunction in mental disorders: a systematic review
In this review we are concerned specifically with the putative role of the default-mode network (DMN) in the pathophysiology of mental disorders. First, we define the DMN concept with regard to its neuro-anatomy, its functional organisation through low frequency neuronal oscillations, its relation to other recently discovered low frequency resting state networks, and the cognitive functions it is thought to serve. Second, we introduce methodological and analytical issues and challenges. Third, we describe putative mechanisms proposed to link DMN abnormalities and mental disorders. These include interference by network activity during task performance, altered patterns of antagonism between task specific and non-specific elements, altered connectively and integrity of the DMN, and altered psychological functions served by the network DMN. Fourth, we review the empirical literature systematically. We relate DMN dysfunction to dementia, schizophrenia, epilepsy, anxiety and depression, autism and attention deficit/hyperactivity disorder drawing out common and unique elements of the disorders. Finally, we provide an integrative overview and highlight important challenges and tasks for future research.
default-mode network, low frequency oscillations, functional connectivity, resting state, alzheimer's disease, schizophrenia, depression, anxiety, epilepsy, autism, attention deficit, hyperactivity disorder, fmri, eeg, meg
0149-7634
279-296
Broyd, Samantha J.
3ff5fb0f-f452-4e84-a260-8e5853f701a3
Demanuele, Charmaine
f5c548d9-6b36-4c28-96b7-c108a590f533
Debener, Stefan
e6bf9143-09a8-45c0-8536-3564885375d4
Helps, Suzannah K.
a80e9c33-f85b-4ecf-b956-9312a6f61fae
James, Christopher J.
c6e71b39-46d2-47c9-a51b-098f428e76e7
Sonuga-Barke, Edmund J.S.
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Broyd, Samantha J.
3ff5fb0f-f452-4e84-a260-8e5853f701a3
Demanuele, Charmaine
f5c548d9-6b36-4c28-96b7-c108a590f533
Debener, Stefan
e6bf9143-09a8-45c0-8536-3564885375d4
Helps, Suzannah K.
a80e9c33-f85b-4ecf-b956-9312a6f61fae
James, Christopher J.
c6e71b39-46d2-47c9-a51b-098f428e76e7
Sonuga-Barke, Edmund J.S.
bc80bf95-6cf9-4c76-a09d-eaaf0b717635

Broyd, Samantha J., Demanuele, Charmaine, Debener, Stefan, Helps, Suzannah K., James, Christopher J. and Sonuga-Barke, Edmund J.S. (2009) Default-mode brain dysfunction in mental disorders: a systematic review. Neuroscience & Biobehavioral Reviews, 33 (3), 279-296. (doi:10.1016/j.neubiorev.2008.09.002).

Record type: Article

Abstract

In this review we are concerned specifically with the putative role of the default-mode network (DMN) in the pathophysiology of mental disorders. First, we define the DMN concept with regard to its neuro-anatomy, its functional organisation through low frequency neuronal oscillations, its relation to other recently discovered low frequency resting state networks, and the cognitive functions it is thought to serve. Second, we introduce methodological and analytical issues and challenges. Third, we describe putative mechanisms proposed to link DMN abnormalities and mental disorders. These include interference by network activity during task performance, altered patterns of antagonism between task specific and non-specific elements, altered connectively and integrity of the DMN, and altered psychological functions served by the network DMN. Fourth, we review the empirical literature systematically. We relate DMN dysfunction to dementia, schizophrenia, epilepsy, anxiety and depression, autism and attention deficit/hyperactivity disorder drawing out common and unique elements of the disorders. Finally, we provide an integrative overview and highlight important challenges and tasks for future research.

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More information

Published date: March 2009
Keywords: default-mode network, low frequency oscillations, functional connectivity, resting state, alzheimer's disease, schizophrenia, depression, anxiety, epilepsy, autism, attention deficit, hyperactivity disorder, fmri, eeg, meg
Organisations: Signal Processing & Control Group, Psychology

Identifiers

Local EPrints ID: 65196
URI: https://eprints.soton.ac.uk/id/eprint/65196
ISSN: 0149-7634
PURE UUID: 635ed1bd-e27e-4a62-aeaf-be7a7169d8bf

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Date deposited: 11 Feb 2009
Last modified: 13 Mar 2019 20:19

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Contributors

Author: Samantha J. Broyd
Author: Charmaine Demanuele
Author: Stefan Debener
Author: Suzannah K. Helps
Author: Christopher J. James
Author: Edmund J.S. Sonuga-Barke

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