The University of Southampton
University of Southampton Institutional Repository

Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes

Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes
Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes
A considerable variability in the sensitivity to glucocorticoids (GCs) exists between individuals and these differences have been implicated in the etiology of psychiatric diseases such as depression. Glucocorticoid receptor (GR) gene polymorphisms might account in part for variability in GC responsiveness. We assessed the association between four common GR gene (NR3C1) polymorphisms (ER22/23EK, N363S, BclI, 9beta) and markers of glucocorticoid sensitivity in two target tissues (subdermal blood vessels, peripheral leukocytes) in 206 healthy individuals. The BclI GG genotype group showed the least degree of skin blanching, reflecting a lower GC sensitivity of subdermal blood vessels (p = .01). No association between GR genotype and GC sensitivity of peripheral leukocytes was observed. In the same subjects we previously observed an association between GR genotype and GC sensitivity of the pituitary. Polymorphism of the GR gene might constitute a vulnerability or protection factor for stress related disorders and altered GC sensitivity.
glucocorticoid receptor gene polymorphisms, hypothalamus–pituitary–adrenal (hpa) axis, glucocorticoid sensitivity, stress
0301-0511
179-184
Kumsta, R.
40cfd543-15ea-44fc-b778-3bfc4ae14f6f
Entringer, S.
7a3581e3-5d89-406b-8631-7bdd3aa78eb8
Koper, J.W.
b35e9497-5af3-41ad-b0e3-ff7210f86d08
van Rossum, E.F.C.
73e37140-d1d3-46c4-ba5a-eaa386ca1c87
Hellhammer, D.H.
2e2b65d7-69f2-40bc-84be-ba10e093c016
Wüst, S.
96e48b7c-9aa0-4279-83d9-86b63e1d6303
Kumsta, R.
40cfd543-15ea-44fc-b778-3bfc4ae14f6f
Entringer, S.
7a3581e3-5d89-406b-8631-7bdd3aa78eb8
Koper, J.W.
b35e9497-5af3-41ad-b0e3-ff7210f86d08
van Rossum, E.F.C.
73e37140-d1d3-46c4-ba5a-eaa386ca1c87
Hellhammer, D.H.
2e2b65d7-69f2-40bc-84be-ba10e093c016
Wüst, S.
96e48b7c-9aa0-4279-83d9-86b63e1d6303

Kumsta, R., Entringer, S., Koper, J.W., van Rossum, E.F.C., Hellhammer, D.H. and Wüst, S. (2008) Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes. Biological Psychology, 79 (2), 179-184. (doi:10.1016/j.biopsycho.2008.04.007).

Record type: Article

Abstract

A considerable variability in the sensitivity to glucocorticoids (GCs) exists between individuals and these differences have been implicated in the etiology of psychiatric diseases such as depression. Glucocorticoid receptor (GR) gene polymorphisms might account in part for variability in GC responsiveness. We assessed the association between four common GR gene (NR3C1) polymorphisms (ER22/23EK, N363S, BclI, 9beta) and markers of glucocorticoid sensitivity in two target tissues (subdermal blood vessels, peripheral leukocytes) in 206 healthy individuals. The BclI GG genotype group showed the least degree of skin blanching, reflecting a lower GC sensitivity of subdermal blood vessels (p = .01). No association between GR genotype and GC sensitivity of peripheral leukocytes was observed. In the same subjects we previously observed an association between GR genotype and GC sensitivity of the pituitary. Polymorphism of the GR gene might constitute a vulnerability or protection factor for stress related disorders and altered GC sensitivity.

This record has no associated files available for download.

More information

Published date: October 2008
Keywords: glucocorticoid receptor gene polymorphisms, hypothalamus–pituitary–adrenal (hpa) axis, glucocorticoid sensitivity, stress

Identifiers

Local EPrints ID: 66089
URI: http://eprints.soton.ac.uk/id/eprint/66089
ISSN: 0301-0511
PURE UUID: ff8a6281-4620-4a0e-b003-6bc477742de3

Catalogue record

Date deposited: 28 Apr 2009
Last modified: 13 Mar 2024 18:09

Export record

Altmetrics

Contributors

Author: R. Kumsta
Author: S. Entringer
Author: J.W. Koper
Author: E.F.C. van Rossum
Author: D.H. Hellhammer
Author: S. Wüst

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×