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?v?6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9

Record type: Article

The integrin ?V?6 is a fibronectin receptor, which is not detectable on normal epithelium but is neo-expressed in oral epithelial dysplasia and oral squamous-cell carcinoma (SCC), suggesting a role in promoting malignant behaviour and tumour progression. We used transfection and retroviral infection to create a panel of SCC cell lines expressing various levels of ?V?6 to examine this possibility. We found that increased expression of ?V?6 in malignant keratinocytes up-regulates MMP-9 and MMP-2 expression and promotes invasion in an MMP-9-dependent manner. Our results suggest a possible mechanism for the involvement of ?V?6 in squamous carcinoma in vivo.

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Citation

Thomas, Gareth J., Lewis, Mark P., Hart, Ian R., Marshall, John F. and Speight, Paul M. (2001) ?v?6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9 International Journal of Cancer, 92, (5), pp. 641-650. (doi:10.1002/1097-0215(20010601)92:5<641::AID-IJC1243>3.0.CO;2-P).

More information

Published date: 1 June 2001

Identifiers

Local EPrints ID: 66693
URI: http://eprints.soton.ac.uk/id/eprint/66693
ISSN: 0020-7136
PURE UUID: d9e81ca9-7772-4fb7-a63d-f3402814172f

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Date deposited: 10 Jul 2009
Last modified: 19 Jul 2017 00:22

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Contributors

Author: Mark P. Lewis
Author: Ian R. Hart
Author: John F. Marshall
Author: Paul M. Speight

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