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???6 Integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes

Thomas, Gareth J., Poomsawat, S., Lewis, Mark P., Hart, Ian R., Speight, Paul M. and Marshall, John F. (2001) ???6 Integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes Journal of Investigative Dermatology, 16, (6), pp. 898-904. (doi:10.1046/j.1523-1747.2001.01352.x).

Record type: Article


The integrin ?v?6 is a fibronectin receptor that is undetectable on normal keratinocytes in situ, but is increased significantly in wound healing and in culture-established keratinocytes, suggesting that it may promote changes associated with cell motility. Using normal human oral keratinocytes we have shown that cultured cells express relatively high levels of ?v?6 and this integrin has a functional role in both cell adhesion and migration towards fibronectin. We provide experimental evidence that the increased expression of ?v?6 by normal human oral keratinocytes results in coordinate changes, which promote a more migratory phenotype. Thus increased expression of ?v?6 results in a fibronectin-dependent increase in pro-matrix metalloproteinase 9, matrix metalloproteinase 9 activity increases normal human oral keratinocyte migration, and this may be further dependent on plasmin activation. The results suggest a key role for ?v?6 in these processes and indicate a coordinated link between ?v?6 expression and upregulation of matrix metalloproteinase 9. It appears that ?v?6 may function in normal human oral keratinocyte migration through matrix-metalloproteinase-9-dependent and -independent mechanisms.

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Published date: June 2001
Keywords: integrins, keratinocytes, metalloproteinases, migration


Local EPrints ID: 66695
ISSN: 0022-202X
PURE UUID: efda7074-2669-410d-901a-036bb52a4429

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Date deposited: 10 Jul 2009
Last modified: 19 Jul 2017 00:22

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Author: S. Poomsawat
Author: Mark P. Lewis
Author: Ian R. Hart
Author: Paul M. Speight
Author: John F. Marshall

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