???6 Integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes


Thomas, Gareth J., Poomsawat, S., Lewis, Mark P., Hart, Ian R., Speight, Paul M. and Marshall, John F. (2001) ???6 Integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes Journal of Investigative Dermatology, 16, (6), pp. 898-904. (doi:10.1046/j.1523-1747.2001.01352.x).

Download

[img] PDF Thomas_et_al.pdf - Version of Record
Restricted to Repository staff only

Download (221kB)

Description/Abstract

The integrin ?v?6 is a fibronectin receptor that is undetectable on normal keratinocytes in situ, but is increased significantly in wound healing and in culture-established keratinocytes, suggesting that it may promote changes associated with cell motility. Using normal human oral keratinocytes we have shown that cultured cells express relatively high levels of ?v?6 and this integrin has a functional role in both cell adhesion and migration towards fibronectin. We provide experimental evidence that the increased expression of ?v?6 by normal human oral keratinocytes results in coordinate changes, which promote a more migratory phenotype. Thus increased expression of ?v?6 results in a fibronectin-dependent increase in pro-matrix metalloproteinase 9, matrix metalloproteinase 9 activity increases normal human oral keratinocyte migration, and this may be further dependent on plasmin activation. The results suggest a key role for ?v?6 in these processes and indicate a coordinated link between ?v?6 expression and upregulation of matrix metalloproteinase 9. It appears that ?v?6 may function in normal human oral keratinocyte migration through matrix-metalloproteinase-9-dependent and -independent mechanisms.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1046/j.1523-1747.2001.01352.x
ISSNs: 0022-202X (print)
Related URLs:
Keywords: integrins, keratinocytes, metalloproteinases, migration
Subjects:

ePrint ID: 66695
Date :
Date Event
June 2001Published
Date Deposited: 10 Jul 2009
Last Modified: 18 Apr 2017 21:31
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/66695

Actions (login required)

View Item View Item