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Research in anxiety disorders: from the bench to the bedside

Research in anxiety disorders: from the bench to the bedside
Research in anxiety disorders: from the bench to the bedside
The development of ethologically based behavioural animal models has clarified the anxiolytic properties of a range of neurotransmitter and neuropeptide receptor agonists and antagonists, with several models predicting efficacy in human clinical samples. Neuro-cognitive models of human anxiety and findings from fMRI suggest dysfunction in amygdalaprefrontal circuitry underlies biases in emotion activation and regulation. Cognitive and neural mechanisms involved in emotion processing can be manipulated pharmacologically, and research continues to identify genetic polymorphisms and interactions with environmental risk factors that co-vary with anxiety-related behaviour and neuro-cognitive endophenotypes. This paper describes findings from a range of research strategies in anxiety, discussed at the recent ECNP Targeted Expert Meeting on anxiety disorders and anxiolytic drugs. The efficacy of existing pharmacological treatments for anxiety disorders is discussed, with particular reference to drugs modulating serotonergic, noradrenergic and gabaergic mechanisms, and novel targets including glutamate, CCK, NPY, adenosine and AVP. Clinical and neurobiological predictors of active treatment and placebo response are considered.
anxiety, treatment, imaging, cognition
0924-977X
381-390
Garner, Matthew
3221c5b3-b951-4fec-b456-ec449e4ce072
Möhler, Hanns
51c40d69-5d27-4272-a9f9-e212ce1b4838
Stein, Dan J.
07cf0cbd-837d-49ac-aceb-1c393a2f3e00
Mueggler, Thomas
e8067958-b34d-4fb0-b2e2-b6ed94b12b6f
Baldwin, David S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Garner, Matthew
3221c5b3-b951-4fec-b456-ec449e4ce072
Möhler, Hanns
51c40d69-5d27-4272-a9f9-e212ce1b4838
Stein, Dan J.
07cf0cbd-837d-49ac-aceb-1c393a2f3e00
Mueggler, Thomas
e8067958-b34d-4fb0-b2e2-b6ed94b12b6f
Baldwin, David S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e

Garner, Matthew, Möhler, Hanns, Stein, Dan J., Mueggler, Thomas and Baldwin, David S. (2009) Research in anxiety disorders: from the bench to the bedside. European Neuropsychopharmacology, 19 (6), 381-390. (doi:10.1016/j.euroneuro.2009.01.011).

Record type: Article

Abstract

The development of ethologically based behavioural animal models has clarified the anxiolytic properties of a range of neurotransmitter and neuropeptide receptor agonists and antagonists, with several models predicting efficacy in human clinical samples. Neuro-cognitive models of human anxiety and findings from fMRI suggest dysfunction in amygdalaprefrontal circuitry underlies biases in emotion activation and regulation. Cognitive and neural mechanisms involved in emotion processing can be manipulated pharmacologically, and research continues to identify genetic polymorphisms and interactions with environmental risk factors that co-vary with anxiety-related behaviour and neuro-cognitive endophenotypes. This paper describes findings from a range of research strategies in anxiety, discussed at the recent ECNP Targeted Expert Meeting on anxiety disorders and anxiolytic drugs. The efficacy of existing pharmacological treatments for anxiety disorders is discussed, with particular reference to drugs modulating serotonergic, noradrenergic and gabaergic mechanisms, and novel targets including glutamate, CCK, NPY, adenosine and AVP. Clinical and neurobiological predictors of active treatment and placebo response are considered.

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More information

Submitted date: 5 January 2009
Published date: 1 June 2009
Keywords: anxiety, treatment, imaging, cognition

Identifiers

Local EPrints ID: 66749
URI: http://eprints.soton.ac.uk/id/eprint/66749
ISSN: 0924-977X
PURE UUID: eb1bdfa4-1472-4bb0-b5ec-6a77f8c8ffb1
ORCID for Matthew Garner: ORCID iD orcid.org/0000-0001-9481-2226
ORCID for David S. Baldwin: ORCID iD orcid.org/0000-0003-3343-0907

Catalogue record

Date deposited: 16 Jul 2009
Last modified: 14 Mar 2024 02:46

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Contributors

Author: Matthew Garner ORCID iD
Author: Hanns Möhler
Author: Dan J. Stein
Author: Thomas Mueggler

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