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Immune-to-brain signalling: the role of cerebral CD163-positive macrophages

Galea, Ian, Felton, Leigh M., Waters, Sara, van Rooijen, Nico, Perry, V. Hugh and Newman, Tracey A. (2008) Immune-to-brain signalling: the role of cerebral CD163-positive macrophages Neuroscience Letters, 448, (1), pp. 41-46. (doi:10.1016/j.neulet.2008.09.081). (PMID:18852025).

Record type: Article


Systemic inflammation induces cytokine synthesis within the central nervous system. This results in sickness behaviour and may exacerbate ongoing neuroinflammatory disease. The precise mechanisms underlying the relay of signal from the periphery to the central nervous system are not entirely understood. CD163-positive macrophages occupy a unique position at the blood-brain barrier and upregulate prostaglandin-synthesizing enzymes in response to systemic inflammation. This finding suggests that they might play a role in signalling inflammation to the central nervous system. However, here we demonstrate that de novo brain cytokine transcription during systemic endotoxaemia may be prostaglandin-independent. We therefore set out to interrogate more directly the role of CD163-positive macrophages in immune-to-brain signalling. Intracerebroventricular injections of clodronate liposomes were used to selectively deplete CD163-positive macrophages. We show that de novo brain cytokine synthesis during systemic endotoxaemia persists in the absence of CD163-positive macrophages. Cerebral endothelial cells outnumber CD163-positive macrophages and are arguably better situated to signal circulating inflammatory stimuli to the brain.

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Published date: 19 December 2008
Organisations: Biological Sciences


Local EPrints ID: 68604
ISSN: 0304-3940
PURE UUID: b24380e4-16a9-4135-8c94-d7ba803693d6
ORCID for Ian Galea: ORCID iD

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Date deposited: 10 Sep 2009
Last modified: 19 Jul 2017 00:18

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Author: Ian Galea ORCID iD
Author: Leigh M. Felton
Author: Sara Waters
Author: Nico van Rooijen
Author: V. Hugh Perry

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