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Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis

Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis
Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis
Objectives: Radiographic osteoarthritis (ROA) has previously been shown to be associated with an increase in areal bone mineral density (BMD) as assessed by dual energy X-ray absorptiometry (DXA). Here we have assessed volumetric bone density, size and strength by peripheral quantitative computed tomography (pQCT) in a large population-based cohort study in which knee radiographs were available.
Methods: Two hundred and ninety-five men and 288 women from the MRC Hertfordshire Cohort Study underwent weight bearing extended knee X-rays and bone density measurement of the ipsi-lateral knee using pQCT.
Results: Increasing radiographic grade in men but not women was associated with an increase in tibial total area at 38% site and cortical area at 14% site, but not with volumetric BMD. The tibial fracture loads as well as tibial polar strength strain index at 38% site were also increased. There were no significant associations of tibia bone area, BMD or strength with radiographic grade in women.
Conclusion: ROA is not associated with an increase in volumetric BMD as assessed by pQCT. It is, however, associated with a significant increase in bone area and strength, indicating that the association between ROA and areal BMD is mediated through bone size rather than volumetric BMD.
bone strength, peripheral quantitative computerised tomography, bone geometry
1063-4584
174-177
Abdin-Mohamed, M.
f9857546-6296-478b-ba26-f2b87d5404b1
Jameson, K.
d5fb142d-06af-456e-9016-17497f94e9f2
Dennison, E.M
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f
Abdin-Mohamed, M.
f9857546-6296-478b-ba26-f2b87d5404b1
Jameson, K.
d5fb142d-06af-456e-9016-17497f94e9f2
Dennison, E.M
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f

Abdin-Mohamed, M., Jameson, K., Dennison, E.M, Cooper, C. and Arden, N.K. (2009) Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis. Osteoarthritis and Cartilage, 17 (2), 174-177. (doi:10.1016/j.joca.2008.06.004).

Record type: Article

Abstract

Objectives: Radiographic osteoarthritis (ROA) has previously been shown to be associated with an increase in areal bone mineral density (BMD) as assessed by dual energy X-ray absorptiometry (DXA). Here we have assessed volumetric bone density, size and strength by peripheral quantitative computed tomography (pQCT) in a large population-based cohort study in which knee radiographs were available.
Methods: Two hundred and ninety-five men and 288 women from the MRC Hertfordshire Cohort Study underwent weight bearing extended knee X-rays and bone density measurement of the ipsi-lateral knee using pQCT.
Results: Increasing radiographic grade in men but not women was associated with an increase in tibial total area at 38% site and cortical area at 14% site, but not with volumetric BMD. The tibial fracture loads as well as tibial polar strength strain index at 38% site were also increased. There were no significant associations of tibia bone area, BMD or strength with radiographic grade in women.
Conclusion: ROA is not associated with an increase in volumetric BMD as assessed by pQCT. It is, however, associated with a significant increase in bone area and strength, indicating that the association between ROA and areal BMD is mediated through bone size rather than volumetric BMD.

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More information

Published date: February 2009
Keywords: bone strength, peripheral quantitative computerised tomography, bone geometry

Identifiers

Local EPrints ID: 68786
URI: https://eprints.soton.ac.uk/id/eprint/68786
ISSN: 1063-4584
PURE UUID: 2ce7b8d4-7efc-4513-a738-bb58653052c7
ORCID for E.M Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 01 Oct 2009
Last modified: 07 Aug 2019 00:50

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