Maternal dietary patterns during pregnancy and childhood bone mass: a longitudinal study
Maternal dietary patterns during pregnancy and childhood bone mass: a longitudinal study
Maternal nutrition is a potentially important determinant of intrauterine skeletal development. Previous studies have examined the effects of individual nutrients, but the pattern of food consumption may be of greater relevance. We therefore examined the relationship between maternal dietary pattern during pregnancy and bone mass of the offspring at 9 yr of age. We studied 198 pregnant women 17–43 yr of age and their offspring at 9 yr of age. Dietary pattern was assessed using principal component analysis from a validated food frequency questionnaire. The offspring underwent measurements of bone mass using DXA at 9 yr of age. A high prudent diet score was characterized by elevated intakes of fruit, vegetables, and wholemeal bread, rice, and pasta and low intakes of processed foods. Higher prudent diet score in late pregnancy was associated with greater (p < 0.001) whole body and lumbar spine BMC and areal BMD in the offspring, after adjustment for sex, socioeconomic status, height, arm circumference, maternal smoking, and vitamin D status. Associations with prudent diet score in early pregnancy were weaker and nonsignificant. We conclude that dietary patterns consistent with current advice for healthy eating during pregnancy are associated with greater bone size and BMD in the offspring at 9 yr of age.
osteoporosis, epidemiology, maternal nutrition, programming, developmental origins
663-668
Cole, Zoe A.
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Gale, Catharine R.
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Javaid, M. Kassim
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Robinson, Sian M.
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Law, Catherine
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Boucher, Barbara J.
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Crozier, Sarah R.
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Godfrey, Keith M.
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Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
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April 2009
Cole, Zoe A.
6802e58a-59b3-4518-bb7d-6f721732cd61
Gale, Catharine R.
5bb2abb3-7b53-42d6-8aa7-817e193140c8
Javaid, M. Kassim
64155236-2ef0-4065-b684-cf723a888117
Robinson, Sian M.
ba591c98-4380-456a-be8a-c452f992b69b
Law, Catherine
b90db04a-7a74-4211-8409-5aad234bca91
Boucher, Barbara J.
de5e1d47-d10f-4c10-be36-8bb5f54361ff
Crozier, Sarah R.
f725a749-98a7-47ba-aa6b-8d8e17c72cad
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Cole, Zoe A., Gale, Catharine R., Javaid, M. Kassim, Robinson, Sian M., Law, Catherine, Boucher, Barbara J., Crozier, Sarah R., Godfrey, Keith M., Dennison, Elaine M. and Cooper, Cyrus
(2009)
Maternal dietary patterns during pregnancy and childhood bone mass: a longitudinal study.
Journal of Bone and Mineral Research, 24 (4), .
(doi:10.1359/jbmr.081212).
Abstract
Maternal nutrition is a potentially important determinant of intrauterine skeletal development. Previous studies have examined the effects of individual nutrients, but the pattern of food consumption may be of greater relevance. We therefore examined the relationship between maternal dietary pattern during pregnancy and bone mass of the offspring at 9 yr of age. We studied 198 pregnant women 17–43 yr of age and their offspring at 9 yr of age. Dietary pattern was assessed using principal component analysis from a validated food frequency questionnaire. The offspring underwent measurements of bone mass using DXA at 9 yr of age. A high prudent diet score was characterized by elevated intakes of fruit, vegetables, and wholemeal bread, rice, and pasta and low intakes of processed foods. Higher prudent diet score in late pregnancy was associated with greater (p < 0.001) whole body and lumbar spine BMC and areal BMD in the offspring, after adjustment for sex, socioeconomic status, height, arm circumference, maternal smoking, and vitamin D status. Associations with prudent diet score in early pregnancy were weaker and nonsignificant. We conclude that dietary patterns consistent with current advice for healthy eating during pregnancy are associated with greater bone size and BMD in the offspring at 9 yr of age.
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Published date: April 2009
Keywords:
osteoporosis, epidemiology, maternal nutrition, programming, developmental origins
Organisations:
Dev Origins of Health & Disease
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Local EPrints ID: 68869
URI: http://eprints.soton.ac.uk/id/eprint/68869
ISSN: 0884-0431
PURE UUID: 22f0f03d-eb19-41b8-b70e-c596e4aa672d
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Date deposited: 07 Oct 2009
Last modified: 18 Mar 2024 02:44
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Author:
Zoe A. Cole
Author:
M. Kassim Javaid
Author:
Sian M. Robinson
Author:
Catherine Law
Author:
Barbara J. Boucher
Author:
Sarah R. Crozier
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