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The Global Longitudinal Study of Osteoporosis in Women (GLOW): rationale and study design

Hooven, F.H., Adachi, J.D., Adami, S., Boonen, S., Compston, J., Cooper, C., Delmas, P., Diez-Perez, A., Gelhbach, S., Greenspan, S.L., LaCroix, A., Lindsay, R., Netenlenbos, J.C., Pfeilschifter, J., Roux, C., Saag, K.C., Sambrook, P., Silverman, S., Siris, E., Watts, N.B. and Anderson Jr, F.A. (2009) The Global Longitudinal Study of Osteoporosis in Women (GLOW): rationale and study design Osteoporosis International, 20, (7), pp. 1107-1116.

Record type: Article


Summary: the Global Longitudinal study of Osteoporosis in Women (GLOW) is a prospective cohort study involving 723 physicians and 60,393 women subjects ?55 years. The data will provide insights into the management of fracture risk in older women over 5 years, patient experience with prevention and treatment, and distribution of risk among older women on an international basis. Introduction: data from cohort studies describing the distribution of osteoporosis-related fractures and risk factors are not directly comparable and do not compare regional differences in patterns of patient management and fracture outcomes. Methods: the GLOW is a prospective, multinational, observational cohort study. Practices typical of each region were identified through primary care networks organized for administrative, research, or educational purposes. Noninstitutionalized patients visiting each practice within the previous 2 years were eligible. Self-administered questionnaires were mailed, with 2:1 oversampling of women ?65 years. Follow-up questionnaires will be sent at 12-month intervals for 5 years. Results: a total of 723 physicians at 17 sites in ten countries agreed to participate. Baseline surveys were mailed (October 2006 to February 2008) to 140,416 subjects. After the exclusion of 3,265 women who were ineligible or had died, 60,393 agreed to participate. Conclusions: GLOW will provide contemporary information on patterns of management of fracture risk in older women over a 5-year period. The collection of data in a similar manner in ten countries will permit comparisons of patient experience with prevention and treatment and provide insights into the distribution of risk among older women on an international basis

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Published date: July 2009
Keywords: fracture, osteoporosis, prevention, risk factors, treatments, women


Local EPrints ID: 68871
ISSN: 0937-941X
PURE UUID: 26b0fcbb-0413-4b5c-b7c6-737cf5dcee14
ORCID for C. Cooper: ORCID iD

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Date deposited: 07 Oct 2009
Last modified: 10 Sep 2017 22:10

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Author: F.H. Hooven
Author: J.D. Adachi
Author: S. Adami
Author: S. Boonen
Author: J. Compston
Author: C. Cooper ORCID iD
Author: P. Delmas
Author: A. Diez-Perez
Author: S. Gelhbach
Author: S.L. Greenspan
Author: A. LaCroix
Author: R. Lindsay
Author: J.C. Netenlenbos
Author: J. Pfeilschifter
Author: C. Roux
Author: K.C. Saag
Author: P. Sambrook
Author: S. Silverman
Author: E. Siris
Author: N.B. Watts
Author: F.A. Anderson Jr

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