DeltaNp73 regulates neuronal survival in vivo

Tissir, Fadel, Ravni, Aurélia, Achouri, Younès, Riethmacher, Dieter, Meyer, Gundela and Goffinet, Andre M. (2009) DeltaNp73 regulates neuronal survival in vivo Proceedings of the National Academy of Sciences of the United States of America, 106, (39), pp. 16871-16876. (doi:10.1073/pnas.0903191106).


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Apoptosis occurs widely during brain development, and p73 transcription factors are thought to play essential roles in this process. The p73 transcription factors are present in two forms, the full length TAp73 and the N-terminally truncated DeltaNp73. In cultured sympathetic neurons, overexpression of DeltaNp73 inhibits apoptosis induced by nerve growth factor withdrawal or p53 overexpression. To probe the function of DeltaNp73 in vivo, we generated a null allele and inserted sequences encoding the recombinase Cre and green fluorescent protein (EGFP). We show that DeltaNp73 is heavily expressed in the thalamic eminence (TE) that contributes neurons to ventral forebrain, in vomeronasal neurons, Cajal-Retzius cells (CRc), and choroid plexuses. In DeltaNp73?/? mice, cells in preoptic areas, vomeronasal neurons, GnRH-positive cells, and CRc were severely reduced in number, and choroid plexuses were atrophic. This phenotype was enhanced when DeltaNp73–positive cells were ablated by diphtheria toxin expression. However, ablation of cells that express DeltaNp73 and Wnt3a did neither remove all CRc, nor did they abolish Reelin secretion or generate a reeler-like cortical phenotype. Our data emphasize the role of DeltaNp73 in neuronal survival in vivo and in choroid plexus development, the importance of the TE as a source of neurons in ventral forebrain, and the multiple origins of CRc, with redundant production of Reelin.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1073/pnas.0903191106
ISSNs: 0027-8424 (print)
Related URLs:
Keywords: Cajal-Retzius cells, p73, Reelin, thalamic eminence, vomeronasal nerve

ePrint ID: 68906
Date :
Date Event
29 September 2009Published
Date Deposited: 08 Oct 2009
Last Modified: 18 Apr 2017 21:18
Further Information:Google Scholar

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