The University of Southampton
University of Southampton Institutional Repository

Fetal growth restriction is associated with prioritization of umbilical blood flow to left hepatic lobe, at the expense of the right lobe

Record type: Article

Eighty to 85% of the venous perfusion to the fetal liver is from the umbilical vein, the rest from the portal vein. Umbilical venous flow to the liver is essential for intrauterine growth, and is impaired in placental insufficiency. We hypothesized that in growth-restricted fetuses portal blood flow compensates for insufficient umbilical blood flow to the liver. In 29 fetuses with fetal growth restriction (estimated fetal weight < or =5th percentile), we used ultrasound to measure blood flows in the umbilical vein, ductus venosus, left portal vein, and main portal stem. Compared with normal fetuses, both absolute and normalized total venous liver blood flows were reduced in growth-restricted fetuses, related to the degree of placental compromise and equally affecting both liver lobes. However, portal replaced umbilical flow to the right lobe, in a manner graded according to placental vascular resistance; in extreme cases, the right lobe received no umbilical perfusion. In fetal growth restriction, the liver suffers from venous hypoperfusion, and portal blood partially replaces umbilical flow to the right lobe; this will result in right liver lobe hypoxemia. This striking prioritization in nutrient delivery of left over right lobes suggests an adaptive response to poor placental perfusion that may have functional consequences

Full text not available from this repository.

Citation

Kessler, Jorg, Rasmussen, Svein, Godfrey, Keith, Hanson, Mark and Kiserud, Torvid (2009) Fetal growth restriction is associated with prioritization of umbilical blood flow to left hepatic lobe, at the expense of the right lobe Pediatric Research, 66, (1), pp. 113-117. (doi:10.1203/PDR.0b013e3181a29077).

More information

Published date: July 2009

Identifiers

Local EPrints ID: 68919
URI: http://eprints.soton.ac.uk/id/eprint/68919
ISSN: 0031-3998
PURE UUID: a3e36109-a2b5-40f5-9255-c6d6e55d067c
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 08 Oct 2009
Last modified: 19 Jul 2017 00:15

Export record

Altmetrics

Contributors

Author: Jorg Kessler
Author: Svein Rasmussen
Author: Keith Godfrey ORCID iD
Author: Mark Hanson
Author: Torvid Kiserud

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×