Impact of glucose metabolism and birth size on cognitive performance in elderly subjects
Impact of glucose metabolism and birth size on cognitive performance in elderly subjects
Aims: We aimed to investigate the impact of diabetes and impaired glucose tolerance on cognitive performance and to explore the association between birth weight and cognitive
performance among diabetic subjects.
Methods: We performed a standard oral glucose tolerance test and a computerised test for assessment of cognitive performance (CogState1) in 1243 subjects; 173 of them had type 2 diabetes. At the time of cognitive testing the mean age of the subjects was 64 years. Subjects with type 1 diabetes or a history of stroke were excluded.
Results: Subjects with known diabetes performed significantly poorer in cognitive tasks measuring visual attention, working memory and episodic learning than subjects with normal glucose tolerance. Subjects with newly diagnosed diabetes or milder impairments in glucose regulation did not differ from the normoglycaemic group. A low birth weight enhanced the association between diabetes and poor performance in the working memory and episodic learning tasks.
Conclusions: Poorer cognitive performance was associated with known type 2 diabetes but not with newly diagnosed diabetes or milder impairments in glucose regulation. Low birth
weight was found to be an additional vulnerability factor enhancing cognitive decline in diabetic subjects.
type 2 diabetes, cognitive performance, birth weight
379-386
Paile-Hyvärinen, Maria
539bff44-c1a1-4899-b388-6fb23df257f7
Räikkönen, Katri
32cd0aa3-6dc2-40a3-b1a0-245ccedd41c3
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Darby, David
9bb83a3f-4116-4c1c-bc1c-5fe42124e2b2
Ylihärsilä, Hilkka
42504362-ed30-4a9f-aa44-40027c901a01
Salonen, Minna K.
0b0a4f25-62d7-4b6e-9716-a68c3ad7988b
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Eriksson, Johan G.
eb96b1c5-af07-4a52-8a73-7541451d32cd
March 2009
Paile-Hyvärinen, Maria
539bff44-c1a1-4899-b388-6fb23df257f7
Räikkönen, Katri
32cd0aa3-6dc2-40a3-b1a0-245ccedd41c3
Kajantie, Eero
d68d55b6-6df1-4195-a914-44c738a6db93
Darby, David
9bb83a3f-4116-4c1c-bc1c-5fe42124e2b2
Ylihärsilä, Hilkka
42504362-ed30-4a9f-aa44-40027c901a01
Salonen, Minna K.
0b0a4f25-62d7-4b6e-9716-a68c3ad7988b
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Eriksson, Johan G.
eb96b1c5-af07-4a52-8a73-7541451d32cd
Paile-Hyvärinen, Maria, Räikkönen, Katri, Kajantie, Eero, Darby, David, Ylihärsilä, Hilkka, Salonen, Minna K., Osmond, Clive and Eriksson, Johan G.
(2009)
Impact of glucose metabolism and birth size on cognitive performance in elderly subjects.
Diabetes Research and Clinical Practice, 83 (3), .
(doi:10.1016/j.diabres.2008.12.010).
Abstract
Aims: We aimed to investigate the impact of diabetes and impaired glucose tolerance on cognitive performance and to explore the association between birth weight and cognitive
performance among diabetic subjects.
Methods: We performed a standard oral glucose tolerance test and a computerised test for assessment of cognitive performance (CogState1) in 1243 subjects; 173 of them had type 2 diabetes. At the time of cognitive testing the mean age of the subjects was 64 years. Subjects with type 1 diabetes or a history of stroke were excluded.
Results: Subjects with known diabetes performed significantly poorer in cognitive tasks measuring visual attention, working memory and episodic learning than subjects with normal glucose tolerance. Subjects with newly diagnosed diabetes or milder impairments in glucose regulation did not differ from the normoglycaemic group. A low birth weight enhanced the association between diabetes and poor performance in the working memory and episodic learning tasks.
Conclusions: Poorer cognitive performance was associated with known type 2 diabetes but not with newly diagnosed diabetes or milder impairments in glucose regulation. Low birth
weight was found to be an additional vulnerability factor enhancing cognitive decline in diabetic subjects.
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More information
Published date: March 2009
Keywords:
type 2 diabetes, cognitive performance, birth weight
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Local EPrints ID: 68987
URI: http://eprints.soton.ac.uk/id/eprint/68987
ISSN: 0168-8227
PURE UUID: 45499cbc-4020-47fa-9d77-90a4377e5e2d
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Date deposited: 13 Oct 2009
Last modified: 14 Mar 2024 02:38
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Contributors
Author:
Maria Paile-Hyvärinen
Author:
Katri Räikkönen
Author:
Eero Kajantie
Author:
David Darby
Author:
Hilkka Ylihärsilä
Author:
Minna K. Salonen
Author:
Johan G. Eriksson
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