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Intergenerational effect of weight gain in childhood on offspring birthweight

Record type: Article

Background: some studies suggest that weight gain in childhood may increase the risk of chronic diseases in adulthood, and recent studies have noticed that the timing of weight gain may be related to its long-term consequence. However, weight gain in childhood has clear short-term benefits, and the literature on the pro and cons of weight gain in childhood is limited.
Methods: in 1982, all 5914 hospital births (over 99% of all deliveries) occurring in Pelotas, Southern Brazil, were identified and studied prospectively on several occasions. In 2004–05, we attempted to trace the whole cohort and information on offspring birthweight was collected. Conditional growth modelling was used to assess the association between offspring birthweight and weight gain from birth to 20 months, and from 20 to 42 months.
Results in 2004–05, we interviewed 4297 subjects, with a follow-up rate of 77.4%. This manuscript includes data from 848 women who had already delivered a child and 525 men who were fathers at the mean age of 23 years. Maternal birthweight, weight and length for age Z-score at 20 months of age were positively associated with next-generation birthweight, whereas paternal variables were not related to the outcome. Conditional growth modelling analyses showed that women whose weight gain in the first 20 months of life was faster than predicted had heavier babies, whereas paternal weight gain was not associated. The association was strongest for mothers whose birthweight for gestational age was in the lowest tertile.
Conclusion: maternal, but not paternal birthweight and weight gain in early childhood are positively associated with next-generation birthweight.

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Citation

Horta, Bernardo L., Gigante, Denise P., Osmond, Clive, Barros, Fernando C. and Victoria, Cesar G. (2009) Intergenerational effect of weight gain in childhood on offspring birthweight International Journal of Epidemiology, 38, (3), pp. 724-732. (doi:10.1093/ije/dyp168).

More information

Published date: June 2009
Keywords: weight gain, intergenerational effect, birthweight
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 68997
URI: http://eprints.soton.ac.uk/id/eprint/68997
ISSN: 0300-5771
PURE UUID: 24c3283b-4a14-4db6-b471-96f00d84a651
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 14 Oct 2009
Last modified: 19 Jul 2017 00:14

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Contributors

Author: Bernardo L. Horta
Author: Denise P. Gigante
Author: Clive Osmond ORCID iD
Author: Fernando C. Barros
Author: Cesar G. Victoria

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