Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variations in newborn size
Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variations in newborn size
Background/Objectives: Vitamin D is required for bone growth and normal insulin secretion. Maternal hypovitaminosis D may
impair fetal growth and increase the risk of gestational diabetes. We have related maternal vitamin D status in pregnancy to
maternal and newborn glucose and insulin concentrations, and newborn size, in a South Indian population.
Subjects/Methods: Serum 25 hydroxy vitamin D (25(OH)D) concentrations, glucose tolerance, and plasma insulin, proinsulin
and 32–33 split proinsulin concentrations were measured at 30 weeks gestation in 559 women who delivered at the Holdsworth
Memorial Hospital, Mysore. The babies’ anthropometry and cord plasma glucose, insulin and insulin precursor concentrations
were measured.
Results: In total 66% of women had hypovitaminosis D (25(OH)D concentrations o50 nmol l1) and 31% were below
28 nmol l1. There was seasonal variation in 25(OH)D concentrations (Po0.0001). There was no association between maternal 25(OH)D and gestational diabetes (incidence 7% in women with and without hypovitaminosis D). Maternal 25(OH)D
concentrations were unrelated to newborn anthropometry or cord plasma variables. In mothers with hypovitaminosis D, higher 25(OH)D concentrations were associated with lower 30-min glucose concentrations (P¼0.03) and higher fasting proinsulin concentrations (P¼0.04).
Conclusions: Hypovitaminosis D at 30 weeks gestation is common in Mysore mothers. It is not associated with an increased risk of gestational diabetes, impaired fetal growth or altered neonatal cord plasma insulin secretory profile.
vitamin D, prenatal nutrition, pregnancy outcome, birth weight, India, gestational diabetes
646-652
Farrant, H.J.W.
1cb193bb-5bdf-49d1-b32e-df4acf0090e8
Krishnaveni, G.V.
e9cc468a-8262-4dde-8eba-e047c68a3dce
Hill, J.C.
418c7f77-f207-4e8d-98fa-7dbe8b2a02c1
Boucher, B.J.
cf2adb5e-1332-42b3-90ad-7e2629aa4798
Fisher, D.J.
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Noonan, K.
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Osmond, C.
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Veena, S.R.
2acd1a9f-ce06-4cd2-bbdb-8f0057308e0e
Fall, C.H.D
7171a105-34f5-4131-89d7-1aa639893b18
May 2009
Farrant, H.J.W.
1cb193bb-5bdf-49d1-b32e-df4acf0090e8
Krishnaveni, G.V.
e9cc468a-8262-4dde-8eba-e047c68a3dce
Hill, J.C.
418c7f77-f207-4e8d-98fa-7dbe8b2a02c1
Boucher, B.J.
cf2adb5e-1332-42b3-90ad-7e2629aa4798
Fisher, D.J.
a22f14ff-7cc9-4e74-ae56-85b0f8b648cc
Noonan, K.
08bd6788-f589-4906-a4e1-b397b057d722
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Veena, S.R.
2acd1a9f-ce06-4cd2-bbdb-8f0057308e0e
Fall, C.H.D
7171a105-34f5-4131-89d7-1aa639893b18
Farrant, H.J.W., Krishnaveni, G.V., Hill, J.C., Boucher, B.J., Fisher, D.J., Noonan, K., Osmond, C., Veena, S.R. and Fall, C.H.D
(2009)
Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variations in newborn size.
European Journal of Clinical Nutrition, 63 (5), .
(doi:10.1038/ejcn.2008.14).
Abstract
Background/Objectives: Vitamin D is required for bone growth and normal insulin secretion. Maternal hypovitaminosis D may
impair fetal growth and increase the risk of gestational diabetes. We have related maternal vitamin D status in pregnancy to
maternal and newborn glucose and insulin concentrations, and newborn size, in a South Indian population.
Subjects/Methods: Serum 25 hydroxy vitamin D (25(OH)D) concentrations, glucose tolerance, and plasma insulin, proinsulin
and 32–33 split proinsulin concentrations were measured at 30 weeks gestation in 559 women who delivered at the Holdsworth
Memorial Hospital, Mysore. The babies’ anthropometry and cord plasma glucose, insulin and insulin precursor concentrations
were measured.
Results: In total 66% of women had hypovitaminosis D (25(OH)D concentrations o50 nmol l1) and 31% were below
28 nmol l1. There was seasonal variation in 25(OH)D concentrations (Po0.0001). There was no association between maternal 25(OH)D and gestational diabetes (incidence 7% in women with and without hypovitaminosis D). Maternal 25(OH)D
concentrations were unrelated to newborn anthropometry or cord plasma variables. In mothers with hypovitaminosis D, higher 25(OH)D concentrations were associated with lower 30-min glucose concentrations (P¼0.03) and higher fasting proinsulin concentrations (P¼0.04).
Conclusions: Hypovitaminosis D at 30 weeks gestation is common in Mysore mothers. It is not associated with an increased risk of gestational diabetes, impaired fetal growth or altered neonatal cord plasma insulin secretory profile.
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Published date: May 2009
Keywords:
vitamin D, prenatal nutrition, pregnancy outcome, birth weight, India, gestational diabetes
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Local EPrints ID: 69001
URI: http://eprints.soton.ac.uk/id/eprint/69001
ISSN: 0954-3007
PURE UUID: a89d2507-4f5d-44fe-82a2-b3cbda0aa096
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Date deposited: 13 Oct 2009
Last modified: 14 Mar 2024 02:38
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Contributors
Author:
H.J.W. Farrant
Author:
G.V. Krishnaveni
Author:
J.C. Hill
Author:
B.J. Boucher
Author:
D.J. Fisher
Author:
K. Noonan
Author:
S.R. Veena
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