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Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones

Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones
Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones
This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in all six patients with two tyrosine kinase pathway mutations. Moreover, in two patients the clones were genetically unrelated by X-chromosome inactivation studies. These data demonstrated clonal diversity in a subset of patients with early stage haematopoietic malignancy and showed, for the first time, that such clones may arise independently
myeloproliferative disorder, cytogenetics, clonality, leukaemia, tyrosine kinases
0007-1048
904-908
Beer, Phillip A.
588fde7a-82bd-4672-8f3b-c69ea7823221
Jones, Amy V.
3d296088-a099-45cf-b227-541ff59d800c
Bench, Anthony J.
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Goday-Fernandez, Andrea
ab1528b9-7158-4d78-87d1-efee3dda5a93
Boyd, ElaineM.
90d56c00-4567-41ff-8412-2acdfd25f943
Vaghela, Krishna J.
dabcae98-b9d4-4118-8f76-fc13135182b2
Erber, Wendy N.
45232fa9-9f1e-4460-8041-109afbf67868
Odeh, Bassam
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Wright, Christine
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McMullin, Mary Frances
feeaf619-229b-4827-ae20-29b9b2b03bf9
Cullis, Jonathan
f8a38fa5-e14d-4387-814d-2d56faa95091
Huntly, Brian J.P.
287595f9-eab5-4914-b1fe-78fadc07cae2
Harrison, Claire N.
a11b7fbb-3212-4d92-b4c7-24624c15e162
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Green, Anthony R.
2723b7ae-f4d6-436b-ab71-fad03823b25c
Beer, Phillip A.
588fde7a-82bd-4672-8f3b-c69ea7823221
Jones, Amy V.
3d296088-a099-45cf-b227-541ff59d800c
Bench, Anthony J.
90d97689-67df-4617-bf72-4d91f1995a1c
Goday-Fernandez, Andrea
ab1528b9-7158-4d78-87d1-efee3dda5a93
Boyd, ElaineM.
90d56c00-4567-41ff-8412-2acdfd25f943
Vaghela, Krishna J.
dabcae98-b9d4-4118-8f76-fc13135182b2
Erber, Wendy N.
45232fa9-9f1e-4460-8041-109afbf67868
Odeh, Bassam
1ccd3205-7334-4d47-82d3-e77722758a2c
Wright, Christine
7a5b5704-5ab5-44d6-a5d5-04e106ec4c97
McMullin, Mary Frances
feeaf619-229b-4827-ae20-29b9b2b03bf9
Cullis, Jonathan
f8a38fa5-e14d-4387-814d-2d56faa95091
Huntly, Brian J.P.
287595f9-eab5-4914-b1fe-78fadc07cae2
Harrison, Claire N.
a11b7fbb-3212-4d92-b4c7-24624c15e162
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Green, Anthony R.
2723b7ae-f4d6-436b-ab71-fad03823b25c

Beer, Phillip A., Jones, Amy V., Bench, Anthony J., Goday-Fernandez, Andrea, Boyd, ElaineM., Vaghela, Krishna J., Erber, Wendy N., Odeh, Bassam, Wright, Christine, McMullin, Mary Frances, Cullis, Jonathan, Huntly, Brian J.P., Harrison, Claire N., Cross, Nicholas C.P. and Green, Anthony R. (2009) Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones. British Journal of Haematology, 144 (6), 904-908. (doi:10.1111/j.1365-2141.2008.07560.x).

Record type: Article

Abstract

This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in all six patients with two tyrosine kinase pathway mutations. Moreover, in two patients the clones were genetically unrelated by X-chromosome inactivation studies. These data demonstrated clonal diversity in a subset of patients with early stage haematopoietic malignancy and showed, for the first time, that such clones may arise independently

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More information

Published date: March 2009
Keywords: myeloproliferative disorder, cytogenetics, clonality, leukaemia, tyrosine kinases

Identifiers

Local EPrints ID: 69514
URI: https://eprints.soton.ac.uk/id/eprint/69514
ISSN: 0007-1048
PURE UUID: a2e6da26-a448-4e19-95fb-fa2097761f01
ORCID for Nicholas C.P. Cross: ORCID iD orcid.org/0000-0001-5481-2555

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Date deposited: 19 Nov 2009
Last modified: 06 Jun 2018 12:49

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Contributors

Author: Phillip A. Beer
Author: Amy V. Jones
Author: Anthony J. Bench
Author: Andrea Goday-Fernandez
Author: ElaineM. Boyd
Author: Krishna J. Vaghela
Author: Wendy N. Erber
Author: Bassam Odeh
Author: Christine Wright
Author: Mary Frances McMullin
Author: Jonathan Cullis
Author: Brian J.P. Huntly
Author: Claire N. Harrison
Author: Anthony R. Green

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