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3-Penten-2-one, a novel aldehyde adduct, is a biomarker for increased acetaldehyde in urine

3-Penten-2-one, a novel aldehyde adduct, is a biomarker for increased acetaldehyde in urine
3-Penten-2-one, a novel aldehyde adduct, is a biomarker for increased acetaldehyde in urine
Diagnostic profiling of urine for volatile compounds of around 400 patients using headspace solid-phase microextraction (HS-SPME) in alkaline conditions identified 3-penten-2-one (approximately 1 to >6.3 ?mol/L) in 26 patients. Five were in barbiturate coma. 3-Penten-2-one, previously of unknown origin, was shown to be formed by aldol condensation of acetaldehyde with acetone or acetoacetate during analysis. Semi-quantification of acetaldehyde using in-fibre derivatisation HS-SPME, showed high concentrations in five urine (33–348 ?mol/L) and two plasma (17 and 43 ?mol/L) samples. Hence, urinary 3-penten-2-one is a useful biomarker for increased accumulation of acetaldehyde during abnormal metabolic stress
3-penten-2-one, acetaldehyde, aldehydes, ALDH2, biological fluids, biomarker, solid-phase microextraction
1570-0232
784-790
Walker, Valerie
e42b352f-5bdd-4ee0-adcd-0ce0fca21a71
Mills, Graham A.
3f99eb9e-1c6c-44ec-ac67-361a6421830a
Standsbridge, Elizabeth M.
d38178de-9342-4f13-83e3-bfb349d70815
Walker, Valerie
e42b352f-5bdd-4ee0-adcd-0ce0fca21a71
Mills, Graham A.
3f99eb9e-1c6c-44ec-ac67-361a6421830a
Standsbridge, Elizabeth M.
d38178de-9342-4f13-83e3-bfb349d70815

Walker, Valerie, Mills, Graham A. and Standsbridge, Elizabeth M. (2009) 3-Penten-2-one, a novel aldehyde adduct, is a biomarker for increased acetaldehyde in urine. Journal of Chromatography B, 877 (8-9), 784-790. (doi:10.1016/j.jchromb.2009.02.017).

Record type: Article

Abstract

Diagnostic profiling of urine for volatile compounds of around 400 patients using headspace solid-phase microextraction (HS-SPME) in alkaline conditions identified 3-penten-2-one (approximately 1 to >6.3 ?mol/L) in 26 patients. Five were in barbiturate coma. 3-Penten-2-one, previously of unknown origin, was shown to be formed by aldol condensation of acetaldehyde with acetone or acetoacetate during analysis. Semi-quantification of acetaldehyde using in-fibre derivatisation HS-SPME, showed high concentrations in five urine (33–348 ?mol/L) and two plasma (17 and 43 ?mol/L) samples. Hence, urinary 3-penten-2-one is a useful biomarker for increased accumulation of acetaldehyde during abnormal metabolic stress

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Published date: March 2009
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Keywords: 3-penten-2-one, acetaldehyde, aldehydes, ALDH2, biological fluids, biomarker, solid-phase microextraction

Identifiers

Local EPrints ID: 69650
URI: http://eprints.soton.ac.uk/id/eprint/69650
DOI: doi:10.1016/j.jchromb.2009.02.017
ISSN: 1570-0232
PURE UUID: 435e672d-74b3-460e-89bd-bca06c8892bf

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Date deposited: 24 Nov 2009
Last modified: 13 Mar 2024 19:40

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Contributors

Author: Valerie Walker
Author: Graham A. Mills
Author: Elizabeth M. Standsbridge

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