Harmonization of molecular monitoring of CML therapy in Europe
Harmonization of molecular monitoring of CML therapy in Europe
The high efficacy of the standard treatment of chronic myeloid leukemia (CML) with imatinib has prompted the need for accurate methods to monitor response at levels below the landmark of complete cytogenetic remission. Quantification of BCR–ABL transcripts has proven to be the most sensitive method available, and has shown prognostic impact with regard to progression-free survival. Until recently, variations in methods used to quantify BCR–ABL made it difficult to compare results between laboratories. An international program is now underway to harmonize the reporting of results according to an international scale (IS). In this review, we consider the background to the IS and the progress that has been made to date, with a particular focus on ongoing harmonization efforts in Europe. We provide recommendations for the propagation of the IS by national or regional laboratory networks.
1957-1963
Müller, M.C.
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Cross, N.C.P.
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Erben, P.
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Schenk, T.
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Hanfstein, B.
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Ernst, T.
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Hehlmann, R.
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Branford, S.
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Saglio, G.
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Houchhaus, A.
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November 2009
Müller, M.C.
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Cross, N.C.P.
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Erben, P.
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Schenk, T.
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Hanfstein, B.
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Ernst, T.
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Hehlmann, R.
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Branford, S.
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Saglio, G.
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Houchhaus, A.
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Müller, M.C., Cross, N.C.P., Erben, P., Schenk, T., Hanfstein, B., Ernst, T., Hehlmann, R., Branford, S., Saglio, G. and Houchhaus, A.
(2009)
Harmonization of molecular monitoring of CML therapy in Europe.
Leukemia, 23 (11), .
(doi:10.1038/leu.2009.168).
Abstract
The high efficacy of the standard treatment of chronic myeloid leukemia (CML) with imatinib has prompted the need for accurate methods to monitor response at levels below the landmark of complete cytogenetic remission. Quantification of BCR–ABL transcripts has proven to be the most sensitive method available, and has shown prognostic impact with regard to progression-free survival. Until recently, variations in methods used to quantify BCR–ABL made it difficult to compare results between laboratories. An international program is now underway to harmonize the reporting of results according to an international scale (IS). In this review, we consider the background to the IS and the progress that has been made to date, with a particular focus on ongoing harmonization efforts in Europe. We provide recommendations for the propagation of the IS by national or regional laboratory networks.
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Published date: November 2009
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Local EPrints ID: 69705
URI: http://eprints.soton.ac.uk/id/eprint/69705
ISSN: 0887-6924
PURE UUID: eb77bc7e-c0a6-4462-93c0-6074abbe77d4
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Date deposited: 30 Nov 2009
Last modified: 14 Mar 2024 02:46
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Contributors
Author:
M.C. Müller
Author:
P. Erben
Author:
T. Schenk
Author:
B. Hanfstein
Author:
T. Ernst
Author:
R. Hehlmann
Author:
S. Branford
Author:
G. Saglio
Author:
A. Houchhaus
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