Mechanisms of action and clinical implications of cardiac urocortin: A journey from the heart to the systemic circulation, with a stopover in the mitochondria
Mechanisms of action and clinical implications of cardiac urocortin: A journey from the heart to the systemic circulation, with a stopover in the mitochondria
The small peptide urocortin (Ucn) has the ability to protect the heart by reducing cardiac cell loss during myocardial ischemia/reperfusion, and improving post-ischemic cardiac performance. Although its mechanism of action is not clearly defined, investigations have revealed that Ucn acts through several kinase pathways, and modulates a group of genes which synergistically minimize mitochondrial damage. Besides cardioprotection, most recent findings suggest a role for Ucn as a cardiac biomarker. Serum Ucn levels may be clinically useful to diagnose cases of mild sub-lethal ischemia, lacking elevation of cardiac enzymes and electrocardiogram changes. Infusion of Ucn may also help reduce the extent of the iatrogenic ischemic/reperfusion injury, associated with cardioplegic arrest
urocortin, ischemia/reperfusion injury, cardioprotection, apoptosis, mitochondria, cardiac biomarkers
189-194
Kuizon, Erlene
dd0bcb68-2f44-4c86-b098-ee0a7ea06dff
Pearce, Eve G.
e92d095b-f06f-471d-9d03-fe45e871074b
Bailey, Sarah G.
3907c846-1c65-490a-81f1-653fea9ff7f0
Chen-Scarabelli, Carol
bf53cd01-66c4-4d7e-859c-9da789e8ba49
Yuan, Zhaokan
3cc1f768-6b54-49a7-a8df-649469241202
Abounit, Kadija
1c636eb5-b81b-4df5-9686-b07bb2412125
McCauley, Roy B.
7fba02d2-7c66-4a50-b9b8-2438c40e5ea6
Saravolatz, Louis
e7a9e7ec-3371-4087-9ed2-db267f3c1d44
Faggian, Giuseppe
9fe6fddd-50db-405b-9a37-9ffe716867d4
Mazzucco, Alessandro
e9b9c701-4968-49c9-b076-106c61bb6468
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Scarabelli, Tiziano M.
ac96a777-880e-4e39-9884-f11a0978da35
November 2009
Kuizon, Erlene
dd0bcb68-2f44-4c86-b098-ee0a7ea06dff
Pearce, Eve G.
e92d095b-f06f-471d-9d03-fe45e871074b
Bailey, Sarah G.
3907c846-1c65-490a-81f1-653fea9ff7f0
Chen-Scarabelli, Carol
bf53cd01-66c4-4d7e-859c-9da789e8ba49
Yuan, Zhaokan
3cc1f768-6b54-49a7-a8df-649469241202
Abounit, Kadija
1c636eb5-b81b-4df5-9686-b07bb2412125
McCauley, Roy B.
7fba02d2-7c66-4a50-b9b8-2438c40e5ea6
Saravolatz, Louis
e7a9e7ec-3371-4087-9ed2-db267f3c1d44
Faggian, Giuseppe
9fe6fddd-50db-405b-9a37-9ffe716867d4
Mazzucco, Alessandro
e9b9c701-4968-49c9-b076-106c61bb6468
Townsend, Paul A.
a2680443-664e-46d0-b4dd-97456ba810db
Scarabelli, Tiziano M.
ac96a777-880e-4e39-9884-f11a0978da35
Kuizon, Erlene, Pearce, Eve G., Bailey, Sarah G., Chen-Scarabelli, Carol, Yuan, Zhaokan, Abounit, Kadija, McCauley, Roy B., Saravolatz, Louis, Faggian, Giuseppe, Mazzucco, Alessandro, Townsend, Paul A. and Scarabelli, Tiziano M.
(2009)
Mechanisms of action and clinical implications of cardiac urocortin: A journey from the heart to the systemic circulation, with a stopover in the mitochondria.
International Journal of Cardiology, 137 (3), .
(doi:10.1016/j.ijcard.2009.03.112).
Abstract
The small peptide urocortin (Ucn) has the ability to protect the heart by reducing cardiac cell loss during myocardial ischemia/reperfusion, and improving post-ischemic cardiac performance. Although its mechanism of action is not clearly defined, investigations have revealed that Ucn acts through several kinase pathways, and modulates a group of genes which synergistically minimize mitochondrial damage. Besides cardioprotection, most recent findings suggest a role for Ucn as a cardiac biomarker. Serum Ucn levels may be clinically useful to diagnose cases of mild sub-lethal ischemia, lacking elevation of cardiac enzymes and electrocardiogram changes. Infusion of Ucn may also help reduce the extent of the iatrogenic ischemic/reperfusion injury, associated with cardioplegic arrest
This record has no associated files available for download.
More information
Published date: November 2009
Keywords:
urocortin, ischemia/reperfusion injury, cardioprotection, apoptosis, mitochondria, cardiac biomarkers
Identifiers
Local EPrints ID: 69718
URI: http://eprints.soton.ac.uk/id/eprint/69718
ISSN: 0167-5273
PURE UUID: 5eff6f10-e58b-4c51-98c8-a506ba0db839
Catalogue record
Date deposited: 07 Dec 2009
Last modified: 13 Mar 2024 19:43
Export record
Altmetrics
Contributors
Author:
Erlene Kuizon
Author:
Eve G. Pearce
Author:
Sarah G. Bailey
Author:
Carol Chen-Scarabelli
Author:
Zhaokan Yuan
Author:
Kadija Abounit
Author:
Roy B. McCauley
Author:
Louis Saravolatz
Author:
Giuseppe Faggian
Author:
Alessandro Mazzucco
Author:
Paul A. Townsend
Author:
Tiziano M. Scarabelli
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics