Mechanisms of action and clinical implications of cardiac urocortin: A journey from the heart to the systemic circulation, with a stopover in the mitochondria

Kuizon, Erlene, Pearce, Eve G., Bailey, Sarah G., Chen-Scarabelli, Carol, Yuan, Zhaokan, Abounit, Kadija, McCauley, Roy B., Saravolatz, Louis, Faggian, Giuseppe, Mazzucco, Alessandro, Townsend, Paul A. and Scarabelli, Tiziano M. (2009) Mechanisms of action and clinical implications of cardiac urocortin: A journey from the heart to the systemic circulation, with a stopover in the mitochondria. International Journal of Cardiology, 137 (3), 189-194. (doi:10.1016/j.ijcard.2009.03.112).

Abstract

The small peptide urocortin (Ucn) has the ability to protect the heart by reducing cardiac cell loss during myocardial ischemia/reperfusion, and improving post-ischemic cardiac performance. Although its mechanism of action is not clearly defined, investigations have revealed that Ucn acts through several kinase pathways, and modulates a group of genes which synergistically minimize mitochondrial damage. Besides cardioprotection, most recent findings suggest a role for Ucn as a cardiac biomarker. Serum Ucn levels may be clinically useful to diagnose cases of mild sub-lethal ischemia, lacking elevation of cardiac enzymes and electrocardiogram changes. Infusion of Ucn may also help reduce the extent of the iatrogenic ischemic/reperfusion injury, associated with cardioplegic arrest

This record has no associated files available for download.

Contributors

Download statistics