Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes
Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes
Aims/hypothesis: this study was designed to test the hypothesis that low plasma vitamin B12 concentrations combined with high folate concentrations in pregnancy are associated with a higher incidence of gestational diabetes (GDM) and later diabetes.
Methods: women (N?=?785) attending the antenatal clinics of one hospital in Mysore, India, had their anthropometry, insulin resistance (homeostasis model assessment-2) and glucose tolerance assessed at 30 weeks’ gestation (100 g oral glucose tolerance test; Carpenter–Coustan criteria) and at 5 years after delivery (75 g OGTT; WHO, 1999). Gestational vitamin B12 and folate concentrations were measured in stored plasma samples.
Results: low vitamin B12 concentrations (<150 pmol/l, B12 deficiency) were observed in 43% of women and low folate concentrations (<7 nmol/l) in 4%. B12-deficient women had higher body mass index (p?<?0.001), sum of skinfold thickness (p?<?0.001), insulin resistance (p?=?0.02) and a higher incidence of GDM (8.7% vs 4.6%; OR 2.1, p?=?0.02; p?=?0.1 after adjusting for BMI) than non-deficient women. Among B12-deficient women, the incidence of GDM increased with folate concentration (5.4%, 10.5%, 10.9% from lowest to highest tertile, p?=?0.04; p for interaction?=?0.2). Vitamin B12 deficiency during pregnancy was positively associated with skinfold thickness, insulin resistance (p?<?0.05) and diabetes prevalence at 5 year follow-up (p?=?0.009; p?=?0.008 after adjusting for BMI). The association with diabetes became non-significant after excluding women with previous GDM (p?=?0.06).
Conclusions/interpretation: maternal vitamin B12 deficiency is associated with increased adiposity and, in turn, with insulin resistance and GDM. Vitamin B12 deficiency may be a
adiposity, diabesity, folate, gestational diabetes, india, insulin resistance, vitamin B12
2350-2358
Krishnaveni, G.V.
e9cc468a-8262-4dde-8eba-e047c68a3dce
Hill, J.C.
418c7f77-f207-4e8d-98fa-7dbe8b2a02c1
Veena, S.R.
2acd1a9f-ce06-4cd2-bbdb-8f0057308e0e
Bhat, D.S.
75412cda-4b68-4286-82e2-8f9ea39fd842
Wills, A.K.
a49cf0bc-8fe1-4672-8ff2-da46760d2059
Karat, C.L.S.
b57295ea-44d2-4607-a007-a3fcce3ecf0c
Yajnik, C.S.
ea0648f2-b384-4e5c-9e0f-45cc852e0c75
Fall, C.H.D.
7171a105-34f5-4131-89d7-1aa639893b18
November 2009
Krishnaveni, G.V.
e9cc468a-8262-4dde-8eba-e047c68a3dce
Hill, J.C.
418c7f77-f207-4e8d-98fa-7dbe8b2a02c1
Veena, S.R.
2acd1a9f-ce06-4cd2-bbdb-8f0057308e0e
Bhat, D.S.
75412cda-4b68-4286-82e2-8f9ea39fd842
Wills, A.K.
a49cf0bc-8fe1-4672-8ff2-da46760d2059
Karat, C.L.S.
b57295ea-44d2-4607-a007-a3fcce3ecf0c
Yajnik, C.S.
ea0648f2-b384-4e5c-9e0f-45cc852e0c75
Fall, C.H.D.
7171a105-34f5-4131-89d7-1aa639893b18
Krishnaveni, G.V., Hill, J.C., Veena, S.R., Bhat, D.S., Wills, A.K., Karat, C.L.S., Yajnik, C.S. and Fall, C.H.D.
(2009)
Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes.
Diabetologia, 52 (11), .
(doi:10.1007/s00125-009-1499-0).
Abstract
Aims/hypothesis: this study was designed to test the hypothesis that low plasma vitamin B12 concentrations combined with high folate concentrations in pregnancy are associated with a higher incidence of gestational diabetes (GDM) and later diabetes.
Methods: women (N?=?785) attending the antenatal clinics of one hospital in Mysore, India, had their anthropometry, insulin resistance (homeostasis model assessment-2) and glucose tolerance assessed at 30 weeks’ gestation (100 g oral glucose tolerance test; Carpenter–Coustan criteria) and at 5 years after delivery (75 g OGTT; WHO, 1999). Gestational vitamin B12 and folate concentrations were measured in stored plasma samples.
Results: low vitamin B12 concentrations (<150 pmol/l, B12 deficiency) were observed in 43% of women and low folate concentrations (<7 nmol/l) in 4%. B12-deficient women had higher body mass index (p?<?0.001), sum of skinfold thickness (p?<?0.001), insulin resistance (p?=?0.02) and a higher incidence of GDM (8.7% vs 4.6%; OR 2.1, p?=?0.02; p?=?0.1 after adjusting for BMI) than non-deficient women. Among B12-deficient women, the incidence of GDM increased with folate concentration (5.4%, 10.5%, 10.9% from lowest to highest tertile, p?=?0.04; p for interaction?=?0.2). Vitamin B12 deficiency during pregnancy was positively associated with skinfold thickness, insulin resistance (p?<?0.05) and diabetes prevalence at 5 year follow-up (p?=?0.009; p?=?0.008 after adjusting for BMI). The association with diabetes became non-significant after excluding women with previous GDM (p?=?0.06).
Conclusions/interpretation: maternal vitamin B12 deficiency is associated with increased adiposity and, in turn, with insulin resistance and GDM. Vitamin B12 deficiency may be a
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Published date: November 2009
Keywords:
adiposity, diabesity, folate, gestational diabetes, india, insulin resistance, vitamin B12
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Local EPrints ID: 69776
URI: http://eprints.soton.ac.uk/id/eprint/69776
ISSN: 0012-186X
PURE UUID: 72230fb0-a236-408a-bae2-57f108152a70
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Date deposited: 04 Dec 2009
Last modified: 14 Mar 2024 02:34
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Author:
G.V. Krishnaveni
Author:
J.C. Hill
Author:
S.R. Veena
Author:
D.S. Bhat
Author:
A.K. Wills
Author:
C.L.S. Karat
Author:
C.S. Yajnik
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